Coreceptors and HIV-1 pathogenesis

被引：100

作者：

Gorry P.R. ^{[1
,2
]}

Ancuta P. ^{[3
,4
,5
]}

机构：

[1] Department of Microbiology and Immunology, University of Melbourne, Melbourne, VIC

[2] Department of Medicine, Monash University, Melbourne, VIC

[3] Department of Microbiology and Immunology, Université de Montréal, Montreal, QC

[4] CHUM-Research Center, Saint-Luc Hospital, Montreal, QC

[5] French National Institute of Health and Medical Research, Montreal, QC

来源：

Current HIV/AIDS Reports | 2011年 / 8卷 / 1期

关键词：

CCR5; CD4+ T cells; Coreceptors; CXCR4; Dendritic cells; HIV-1; Macrophages; Monocytes; Pathogenesis; Reservoirs; Tropism;

D O I：

10.1007/s11904-010-0069-x

中图分类号：

学科分类号：

摘要：

The major HIV-1 coreceptors, CCR5 and CXCR4, mediate virus entry into CD4+ cells and are therefore a critical component of the HIV-1 life cycle. Alterations in coreceptor preference as well as the efficiency and mechanism of interaction between HIV-1 and CCR5 and/or CXCR4 has a significant influence on viral tropism, progression of disease, and response to coreceptor antagonists. In addition, these alterations influence the susceptibility of CD4+ T-cell, monocyte, and dendritic cell subsets to infection and therefore, are important for several facets of HIV-1 pathogenesis including the establishment of latent reservoirs, trafficking, and transmission. This review highlights recent literature that has advanced our understanding of the role of coreceptors in HIV-1 pathogenesis. © 2010 Springer Science+Business Media, LLC.

引用

页码：45 / 53

页数：8

共 50 条

[1]

Jakobsen M.R., Ellett A., Churchill M.J., Gorry P.R., Viral tropism, fitness and pathogenicity of HIV-1 subtype C, Future Virology, 5, pp. 219-231, (2010)

[2]

Sterjovski J., Roche M., Churchill M.J., Ellett A., Farrugia W., Gray L.R., Cowley D., Poumbourios P., Lee B., Wesselingh S., Cunningham A.L., Ramsland P.A., Gorry P.R., An altered and more efficient mechanism of CCR5 engagement contributes to macrophage tropism of CCR5-using HIV-1 envelopes, Virology, 404, pp. 269-278, (2010)

[3]

Samson M., Libert F., Doranz B.J., Rucker J., Liesnard C., Farber C.M., Saragosti S., Lapoumeroulie C., Cognaux J., Forceille C., Muyldermans G., Verhofstede C., Burtonboy G., Georges M., Imai T., Rana S., Yi Y., Smyth R.J., Collman R.G., Doms R.W., Vassart G., Parmentier M., Resistance to HIV-1 infection in caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene, Nature, 382, pp. 722-725, (1996)

[4]

Casazza J.P., Brenchley J.M., Hill B.J., Ayana R., Ambrozak D., Roederer M., Douek D.C., Betts M.R., Koup R.A., Autocrine production of beta-chemokines protects CMV-Specific CD4 T cells from HIV infection, PLoS Pathog, 5, (2009)

[5]

Hutter G., Nowak D., Mossner M., Ganepola S., Mussig A., Allers K., Schneider T., Hofmann J., Kucherer C., Blau O., Blau I.W., Hofmann W.K., Thiel E., Long-term control of HIV by CCR5 Delta32/Delta32 stem-cell transplantation, N Engl J Med, 360, pp. 692-698, (2009)

[6]

Pandrea I., Apetrei C., Gordon S., Barbercheck J., Dufour J., Bohm R., Sumpter B., Roques P., Marx P.A., Hirsch V.M., Kaur A., Lackner A.A., Veazey R.S., Silvestri G., Paucity of CD4+CCR5+ T cells is a typical feature of natural SIV hosts, Blood, 109, pp. 1069-1076, (2007)

[7]

Coetzer M., Nedellec R., Salkowitz J., McLaughlin S., Liu Y., Heath L., Mullins J.I., Mosier D.E., Evolution of CCR5 use before and during coreceptor switching, J Virol, 82, pp. 11758-11766, (2008)

[8]

Coetzer M., Nedellec R., Cilliers T., Meyers T., Morris L., Mosier D.E., Extreme genetic divergence is required for coreceptor switching in HIV-1 subtype C, Journal of Acquired Immune Deficiency Syndromes, 56, pp. 9-15, (2011)

[9]

Wade J., Sterjovski J., Gray L., Roche M., Chiavaroli L., Ellett A., Jakobsen M.R., Cowley D., Da Fonseca Pereira C., Saksena N., Wang B., Purcell D.F., Karlsson I., Fenyo E.M., Churchill M., Gorry P.R., Enhanced CD4+ cellular apoptosis by CCR5-restricted HIV-1 envelope glycoprotein variants from patients with progressive HIV-1 infection, Virology, 396, pp. 246-255, (2010)

[10]

Sterjovski J., Churchill M.J., Ellett A., Gray L.R., Roche M.J., Dunfee R.L., Purcell D.F., Saksena N., Wang B., Sonza S., Wesselingh S.L., Karlsson I., Fenyo E.M., Gabuzda D., Cunningham A.L., Gorry P.R., Asn 362 in gp120 contributes to enhanced fusogenicity by CCR5-restricted HIV-1 envelope gly-coprotein variants from patients with AIDS, Retrovirology, 4, (2007)

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