The CNS microvascular pericyte: Pericyte-astrocyte crosstalk in the regulation of tissue survival

被引：144

作者：

Bonkowski D. ^{[1
,2
]}

Katyshev V. ^{[1
,3
]}

Balabanov R.D. ^{[4
]}

Borisov A. ^{[5
]}

Dore-Duffy P. ^{[1
]}

机构：

[1] Department of Neurology, Wayne State University School of Medicine, Detroit, MI 48201

[2] Department of Neuroscience, University of Michigan, Ann Arbor, MI

[3] Department of Neurology Wayne State University School of Medicine, Detroit

[4] Department of Neurology, Rush University Medical Center, Chicago

[5] Department of Biology, Wayne State University, Detroit

来源：

Fluids and Barriers of the CNS | / 8卷 / 1期

基金：

美国国家卫生研究院;

关键词：

Vascular Endothelial Growth Factor; Traumatic Brain Injury; Glial Fibrillary Acidic Protein; Basal Lamina; Neurovascular Unit;

D O I：

10.1186/2045-8118-8-8

中图分类号：

学科分类号：

摘要：

The French scientist Charles Benjamin Rouget identified the pericyte nearly 140 years ago. Since that time the role of the pericyte in vascular function has been difficult to elucidate. It was not until the development of techniques to isolate and culture pericytes that scientists have begun to understand the true impact of this unique cell in the maintenance of tissue homeostasis. In the brain the pericyte is an integral cellular component of the blood-brain barrier and, together with other cells of the neurovascular unit (endothelial cells, astrocytes and neurons) the pericyte makes fine-tuned regulatory adjustments and adaptations to promote tissue survival. These regulatory changes involve trans-cellular communication networks between cells. In this review we consider evidence for cell-to-cell crosstalk between pericytes and astrocytes during development and in adult brain. © 2011 Bonkowski et al; licensee BioMed Central Ltd.

引用

共 170 条

[1]

del Zoppo G.J., The neurovascular unit in the setting of stroke, J Intern Med, 267, pp. 156-171, (2010)

[2]

Nag S., Kapadia A., Stewart D.J., Molecular Pathogenesis of Blood-Brain Barrier Breakdown in Acute Brain Injury, Neuropathol Appl Neurobiol, (2010)

[3]

Balabanov R., Dore-Duffy P., Role of the CNS microvascular pericyte in the blood-brain barrier, J Neurosci Res, 53, pp. 637-644, (1998)

[4]

Fisher M., Pericyte signaling in the neurovascular unit, Stroke, 40, (2009)

[5]

Sims D.E., Recent advances in pericyte biology--implications for health and disease, Can J Cardiol, 7, pp. 431-443, (1991)

[6]

Tilton R.G., Capillary pericytes: perspectives and future trends, J Electron Microsc Tech, 19, pp. 327-344, (1991)

[7]

Shepro D., Morel N.M., Pericyte physiology, FASEB J, 7, pp. 1031-1038, (1993)

[8]

Nakaoke R., Verma S., Niwa M., Doghu S., Banks W.A., Glucose regulated blood-brain barrier transport of insulin: Pericyte-astrocyte-endothelial cell cross talk, IJNN, 3, pp. 195-200, (2007)

[9]

Charbord P., Oostendorp R., Pang W., Herault O., Noel F., Tsuji T., Dzierzak E., Peault B., Comparative study of stromal cell lines derived from embryonic, fetal, and postnatal mouse blood-forming tissues, Exp Hematol, 30, pp. 1202-1210, (2002)

[10]

Rouget C., Note sur le developpement de la tunique contractile des vaisseaux, Compt Rend Acad Sci, 59, pp. 559-562, (1874)

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