Amino acids as regulators of gene expression

被引：50

作者：

Kimball S.R. ^{[1
]}

Jefferson L.S. ^{[1
]}

机构：

[1] Dept. of Cell. and Molec. Physiology, Pennsylvania State University, College of Medicine, Hershey

来源：

Nutrition & Metabolism | / 1卷 / 1期

关键词：

Internal Ribosome Entry Site; Amino Acid Availability; Internal Ribosome Entry Site Element; Amino Acid Deprivation; S6K1 Phosphorylation;

D O I：

10.1186/1743-7075-1-3

中图分类号：

学科分类号：

摘要：

The role of amino acids as substrates for protein synthesis is well documented. However, a function for amino acids in modulating the signal transduction pathways that regulate mRNA translation has only recently been described. Interesting, some of the signaling pathways regulated by amino acids overlap with those classically associated with the cellular response to hormones such as insulin and insulin-like growth factors. The focus of this review is on the signaling pathways regulated by amino acids, with a particular emphasis on the branched-chain amino acid leucine, and the steps in mRNA translation controlled by the signaling pathways. © 2004 Kimball and Jefferson; licensee BioMed Central Ltd.

引用

共 78 条

[1]

Sonenberg N., Dever T.E., Eukaryotic translation initiation factors and regulators, Current Opinion in Structural Biology, 13, pp. 56-63, (2003)

[2]

Dever T.E., Gene-specific regulation by general translation factors, Cell, 108, pp. 545-556, (2002)

[3]

Kimball S.R., Horetsky R.L., Jefferson L.S., Implication of eIF2B rather than eIF4E in the regulation of global protein synthesis by amino acids in L6 myoblasts, J Biol Chem, 273, pp. 30945-30953, (1998)

[4]

Kimball S.R., Jefferson L.S., Mechanism of inhibition of peptide chain initiation by amino acid deprivation in perfused rat liver. Regulation involving inhibition of eukaryotic Initiation Factor 2α phosphatase activity, J Biol Chem, 266, 3, pp. 1969-1976, (1991)

[5]

Kimball S.R., Anthony T.G., Cavener D.R., Jefferson L.S., Nutrient signaling through mammalian GCN2, Topic Curr Genet, 7, pp. 113-130, (2004)

[6]

Zhang P., McGrath B.C., Reinert J., Olsen D.S., Lei L., Gill S., Wek S.A., Vattem K.M., Wek R.C., Kimball S.R., Et al., The GCN2 eIF2α kinase is required for adaptation to amino acid deprivation in mice, Molec Cell Biol, 22, 19, pp. 6681-6688, (2002)

[7]

Harding H.P., Novoa I., Zhang Y., Zeng H., Wek R.C., Schapira M., Ron D., Regulated translation initiation controls stress-induced gene expression in mammalian cells, Molec Cell, 6, pp. 1099-1108, (2000)

[8]

Yoshizawa F., Endo M., Ide H., Yagasaki K., Funabiki R., Translational regulation of protein synthesis in the liver and skeletal muscle of mice in response to refeeding, J Nutr Biochem, 6, pp. 130-136, (1995)

[9]

Anthony T.G., Reiter A.K., Anthony J.C., Kimball S.R., Jefferson L.S., Deficiency of dietary EAA preferentially inhibits mRNA translation of ribosomal proteins in the liver of meal-fed rats, Am J Physiol, 281, (2001)

[10]

Fernandez J., Bode B., Koromilias A., Diehl J.A., Krukovets I., Snider M.D., Hatzoglou M., Translation mediated by the internal ribosome entry site of the cat-1 mRNA is regulated by glucose availablity in a PERK kinase-dependent manner, J Biol Chem, 277, pp. 11780-11787, (2002)

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