Pollen allergens do not come alone: Pollen associated lipid mediators (PALMS) shift the human immue systems towards a TH2-dominated response

被引：43

作者：

Gilles S. ^{[1
]}

Mariani V. ^{[2
]}

Bryce M. ^{[1
]}

Mueller M.J. ^{[3
]}

Ring J. ^{[4
]}

Behrendt H. ^{[1
]}

Jakob T. ^{[5
]}

Traidl-Hoffmann C. ^{[1
]}

机构：

[1] ZAUM - Center for Allergy and Environment, Division of Environmental Dermatology and Allergy Helmholz Center/TUM, 80802 Munich

[2] Istituto dermopatico dell immacolata, Rome

[3] Julius-von-Sachs-Institute of Biosciences, Division of Pharmaceutical Biology, University of Würzburg, Würzburg

[4] Department of Dermatology and Allergy Biederstein, Technische Universität München, Munich

[5] Allergy Research Group, University Medical Center Freiburg, Freiburg

来源：

Allergy, Asthma & Clinical Immunology | / 5卷 / 1期

关键词：

Allergic Sensitization; Mixed Lymphocyte Reaction; Pollen Release; Migratory Phenotype; Allogenic Mixed Lymphocyte Reaction;

D O I：

10.1186/1710-1492-5-3

中图分类号：

学科分类号：

摘要：

Pollen allergy is characterized by a TH2-biased immune response to pollen-derived allergens. However, pollen-exposed epithelia do not encounter pure allergen but rather a plethora of protein and non-protein substances. We demonstrated that pollen liberate lipids with chemical and functional similarities to leukotriens and prostaglandins - the pollen associated lipid mediators (PALMs). To date, two main groups of PALMs have been characterized: The immunostimulatory PALMs activating innate immune cells such as neutrophils and eosinophils, and the immunomodulatory E1-phytoprostanes blocking IL-12 production of dendritic cells, resulting in the preferential induction of TH2 responses. This article reviews our work in the field of PALMs and their effects on cells of the innate and adoptive immune system. From recent results a general picture starts to emerge in which PALMs (and possibly other pollen-associated substances) may - independently from protein allergens - propagate an overall TH2 favoring micromilieu in pollen exposed tissue of predisposed individuals. © 2009 Gilles et al; licensee BioMed Central Ltd.

引用

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