Procalcitonin concentrations in patients with neutropenic fever

被引：65

作者：

Ruokonen E. ^{[1
]}

Nousiainen T. ^{[2
]}

Pulkki K. ^{[3
]}

Takala J. ^{[1
]}

机构：

[1] Critical Care Research Program, Dept. of Anaesthiol./Intensive Care, Kuopio University Hospital, PO Box 1777

[2] Department of Internal Medicine, Kuopio University Hospital, Kuopio

[3] Department of Clinical Chemistry, Turku University Central Hospital, Turku

来源：

European Journal of Clinical Microbiology and Infectious Diseases | 1999年 / 18卷 / 4期

关键词：

Acute Myeloid Leukemia; Procalcitonin; Neopterin; Neutropenic Patient; Hairy Cell Leukemia;

D O I：

10.1007/s100960050277

中图分类号：

学科分类号：

摘要：

To assess the usefulness of markers of inflammation in distinguishing bacterial infection from severe systemic nonbacterial inflammation, concentrations of procalcitonin, neopterin, endotoxin, tumor necrosis factor, and interleukin-6 were measured in 28 neutropenic patients at the onset of fever and twice thereafter at 4 h intervals. Infection was found in 11 patients, and 17 patients had fever of undetermined origin. The procalcitonin concentration increased rapidly in patients with infection; the response was detectable within 8 h of the onset of fever. Procalcitonin is a specific but not a sensitive marker of infection in patients with neutropenic fever. Its poor sensitivity was related to an absent or delayed response in patients with gram-positive infections. Considerable overlap between infected and noninfected patients was found in levels of endotoxin, tumor necrosis factor, and interleukin-6.

引用

页码：283 / 285

页数：2

共 12 条

[1]

Manian, F.A., A prospective study of daily measurement of C-reactive protein in serum of adults with neutropenia (1995) Clinical Infectious Diseases, 21, pp. 114-121

[2]

De Werra, I., Jaccard, C., Betz Corradin, S., Chiolero, R., Yersin, B., Gallati, H., Assicot, M., Heumann, D., Cytokines, nitrite/nitrate, soluble tumor necrosis factor receptors, and procalcitonin concentrations: Comparisons in patients with septic shock, cardiogenic shock, and bacterial pneumonia (1997) Critical Care Medicine, 25, pp. 607-613

[3]

Rintala, E., Pulkki, K., Mertsola, J., Nevalainen, T., Nikoskelainen, J., Endotoxin, interleukin-6 and phospholipase -A2 as markers of sepsis in patients with hematological malignancies (1995) Scandinavian Journal of Infectious Diseases, 27, pp. 39-43

[4]

Bayston, K.F., Cohen, J., Bacterial endotoxin and current concepts in the diagnosis and treatment of endotoxemia (1990) Journal of Medical Microbiology, 311, pp. 73-83

[5]

Hynninen, M., Valtonen, M., Vaara, M., Markkanen, H., Kuusela, P., Saxen, H., Takkunen, O., Plasma endotoxin and cytokine levels in neutropenic and non-neutropenic bacteremic patients (1995) European Journal of Clinical Microbiology & Infectious Diseases, 14, pp. 1039-1045

[6]

Engervall, P., Granström, M., Andersson, B., Björkholm, M., Monitoring of endotoxin, interleukin-6 and C-reactive protein serum concentrations in neutropenic patients with fever (1995) European Journal of Haematology, 54, pp. 226-234

[7]

Schonbohn, H., Schuler, M., Kolbe, K., Peschel, C., Huber, C., Bemb, W., Aulitzky, W.E., Plasma levels of IL-1, TNF alpha, IL-6, IL-8, G-CSF, and IL1-RA during febrile neutropenia: Results of a prospective study in patients undergoing chemotherapy for acute myelogenous leukemia (1995) Annals of Hematology, 71, pp. 161-168

[8]

Assicot, M., Gendrel, D., Carsin, H., Raymond, J., Guildbaud, J., Bohuon, C., High serum procalcitonin concentrations in patients with sepsis and infection (1993) Lancet, 341, pp. 515-518

[9]

Gendrel, D., Bohuon, C., Procalcitonin, a marker of bacterial infection (1997) Infection, 25, pp. 133-134

[10]

Dandona, P., Nix, D., Wilson, M.F., Aljada, A., Love, J., Assicot, M., Bohuon, C., Procalcitonin increase after endotoxin injection in normal subjects (1994) Journal of Clinical Endocrinology and Metabolism, 79, pp. 1605-1608

← 1 2 →