The obesity epidemic and nonalcoholic fatty liver disease in children

被引：84

作者：

Dunn W. ^{[1
]}

Schwimmer J.B. ^{[1
]}

机构：

[1] Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of California, San Diego, CA 92103

来源：

Current Gastroenterology Reports | 2008年 / 10卷 / 1期

基金：

美国国家卫生研究院;

关键词：

Metformin; Fatty Liver; NASH; Obese Child; Adiponectin Level;

D O I：

10.1007/s11894-008-0011-1

中图分类号：

学科分类号：

摘要：

Childhood obesity is a worldwide health problem associated with an increase in the prevalence and severity of nonalcoholic fatty liver disease (NAFLD). This review covers the progress made between 2005 and 2007 in understanding the epidemiology, histology, and treatment of pediatric NAFLD. The number of children with NAFLD presents a major public health crisis. Noninvasive diagnostic tools offer future promise, but currently are unable to grade and stage disease. Therefore, pediatric NAFLD remains a clinico-pathological diagnosis requiring direct demonstration of liver steatosis and the exclusion of other causes of fatty liver and/or hepatitis. There are currently no proven therapies for NAFLD in children; however, TONIC (Treatment of Nonalcoholic Fatty Liver Disease in Children), the first multicenter clinical trial of pediatric NAFLD, is currently in progress. Such studies are imperative to address fundamental questions regarding cause and cure. © Springer Science+Business Media, LLC 2008.

引用

页码：67 / 72

页数：5

共 30 条

[1]

Ogden C.L., Carroll M.D., Curtin L.R., Et al., Prevalence of overweight and obesity in the United States, 1999-2004, JAMA, 295, pp. 1549-1555, (2006)

[2]

Janssen I., Katzmarzyk P.T., Boyce W.F., Et al., Comparison of overweight and obesity prevalence in school-aged youth from 34 countries and their relationships with physical activity and dietary patterns, Obes Rev, 6, pp. 123-132, (2005)

[3]

Park H.S., Han J.H., Choi K.M., Kim S.M., Relation between elevated serum alanine aminotransferase and metabolic syndrome in Korean adolescents, Am J Clin Nutr, 82, pp. 1046-1051, (2005)

[4]

Muntner P., He J., Cutler J.A., Et al., Trends in blood pressure among children and adolescents, JAMA, 291, pp. 2107-2113, (2004)

[5]

Williams D.E., Cadwell B.L., Cheng Y.J., Et al., Prevalence of impaired fasting glucose and its relationship with cardiovascular disease risk factors in US adolescents, 1999-2000, Pediatrics, 116, pp. 1122-1126, (2005)

[6]

Burgert T.S., Taksali S.E., Dziura J., Et al., Alanine aminotransferase levels and fatty liver in childhood obesity: Associations with insulin resistance, adiponectin, and visceral fat, J Clin Endocrinol Metab, 91, pp. 4287-4294, (2006)

[7]

Pacifico L., Celestre M., Anania C., Et al., MRI and ultrasound for hepatic fat quantification: Relationships to clinical and metabolic characteristics of pediatric nonalcoholic fatty liver disease, Acta Paediatr, 96, pp. 542-547, (2007)

[8]

Schwimmer J.B., Behling C., Newbury R., Et al., Histopathology of pediatric nonalcoholic fatty liver disease, Hepatology, 42, pp. 641-649, (2005)

[9]

Nobili V., Marcellini M., Devito R., Et al., NAFLD in children: A prospective clinical-pathological study and effect of lifestyle advice, Hepatology, 44, pp. 458-465, (2006)

[10]

Xanthakos S., Miles L., Bucuvalas J., Et al., Histologic spectrum of nonalcoholic fatty liver disease in morbidly obese adolescents, Clin Gastroenterol Hepatol, 4, pp. 226-232, (2006)

← 1 2 3 →