Multiplicity of cerebrospinal fluid functions: New challenges in health and disease

被引：550

作者：

Johanson C.E. ^{[1
]}

Duncan III J.A. ^{[1
]}

Klinge P.M. ^{[2
]}

Brinker T. ^{[2
]}

Stopa E.G. ^{[1
]}

Silverberg G.D. ^{[1
]}

机构：

[1] Department of Clinical Neurosciences, Warren Alpert Medical School, Brown University, Providence

[2] International Neuroscience Institute Hannover, 30625 Hannover

来源：

Cerebrospinal Fluid Research | / 5卷 / 1期

基金：

美国国家卫生研究院;

关键词：

Hydrocephalus; Atrial Natriuretic Peptide; Choroid Plexus; Normal Pressure Hydrocephalus; Congenital Hydrocephalus;

D O I：

10.1186/1743-8454-5-10

中图分类号：

学科分类号：

摘要：

This review integrates eight aspects of cerebrospinal fluid (CSF) circulatory dynamics: Formation rate, pressure, flow, volume, turnover rate, composition, recycling and reabsorption. Novel ways to modulate CSF formation emanate from recent analyses of choroid plexus transcription factors (E2F5), ion transporters (NaHCO3 cotransport), transport enzymes (isoforms of carbonic anhydrase), aquaporin 1 regulation, and plasticity of receptors for fluid-regulating neuropeptides. A greater appreciation of CSF pressure (CSFP) is being generated by fresh insights on peptidergic regulatory servomechanisms, the role of dysfunctional ependyma and circumventricular organs in causing congenital hydrocephalus, and the clinical use of algorithms to delineate CSFP waveforms for diagnostic and prognostic utility. Increasing attention focuses on CSF flow: How it impacts cerebral metabolism and hemodynamics, neural stem cell progression in the subventricular zone, and catabolite/peptide clearance from the CNS. The pathophysiological significance of changes in CSF volume is assessed from the respective viewpoints of hemodynamics (choroid plexus blood flow and pulsatility), hydrodynamics (choroidal hypo- and hypersecretion) and neuroendocrine factors (i.e., coordinated regulation by atrial natriuretic peptide, arginine vasopressin and basic fibroblast growth factor). In aging, normal pressure hydrocephalus and Alzheimer's disease, the expanding CSF space reduces the CSF turnover rate, thus compromising the CSF sink action to clear harmful metabolites (e.g., amyloid) from the CNS. Dwindling CSF dynamics greatly harms the interstitial environment of neurons. Accordingly the altered CSF composition in neurodegenerative diseases and senescence, because of adverse effects on neural processes and cognition, needs more effective clinical management. CSF recycling between subarachnoid space, brain and ventricles promotes interstitial fluid (ISF) convection with both trophic and excretory benefits. Finally, CSF reabsorption via multiple pathways (olfactory and spinal arachnoidal bulk flow) is likely complemented by fluid clearance across capillary walls (aquaporin 4) and arachnoid villi when CSFP and fluid retention are markedly elevated. A model is presented that links CSF and ISF homeostasis to coordinated fluxes of water and solutes at both the blood-CSF and blood-brain transport interfaces. © 2008 Johanson et al; licensee BioMed Central Ltd.

引用

共 170 条

[1]

Johanson C., Choroid plexus-CSF circulatory dynamics: Impact on brain growth, metabolism and repair, Neuroscience in Medicine, (2008)

[2]

Redzic Z.B., Preston J.E., Duncan J.A., Chodobski A., Szmydynger-Chodobska J., The choroid plexus-cerebrospinal fluid system: From development to aging, Curr Top Dev Biol, 71, pp. 1-52, (2005)

[3]

Silverberg G.D., Heit G., Huhn S., Jaffe R.A., Chang S.D., Bronte-Stewart H., Rubenstein E., Possin K., Saul T.A., The cerebrospinal fluid production rate is reduced in dementia of the Alzheimer's type, Neurology, 57, pp. 1763-1766, (2001)

[4]

Pliushcheva N., Shakhnovich A., CSF dynamics in patients with meningiomas, Acta Neurochir Suppl (Wien), 60, pp. 174-175, (1994)

[5]

Levine S., Choroid plexus: Target for systemic disease and pathway to the brain, Lab Invest, 56, pp. 231-233, (1987)

[6]

Weaver C., McMillan P., Duncan J.A., Stopa E., Johanson C., Hydrocephalus disorders: Their biophysical and neuroendocrine impact on the choroid plexus epithelium, Non-Neuronal Cells of the Nervous System: Function and Dysfunction, 31, pp. 269-293, (2004)

[7]

Johanson C., McMillan P., Palm D., Stopa E., Doberstein C., Duncan J.A., Volume transmission-mediated protective impact of choroid plexus-CSF growth factors on forebrain ischemic injury, Blood-Spinal Cord and Brain Barriers in Health and Disease, pp. 361-384, (2003)

[8]

Ennis S.R., Keep R.F., The effects of cerebral ischemia on the rat choroid plexus, J Cereb Blood Flow Metab, 26, pp. 675-683, (2006)

[9]

Rubenstein E., Relationship of senescence of cerebrospinal fluid circulatory system to dementias of the aged, Lancet, 351, pp. 283-285, (1998)

[10]

Emerich D.F., Skinner S.J., Borlongan C.V., Vasconcellos A.V., Thanos C.G., The choroid plexus in the rise, fall and repair of the brain, Bioessays, 27, pp. 262-274, (2005)

← 1 2 3 4 5 6 7 8 9 10 →