Disrupted-in-Schizophrenia-1

被引：30

作者：

Muir W. ^{[1
]}

Piekard B.S. ^{[1
]}

Blackwood D.H.R. ^{[1
]}

机构：

[1] Division of Psychiatry, School of Molecular and Clinical Medicine, University of Edinburgh, Edinburgh EH10 5HF, Morningside Park

来源：

Current Psychiatry Reports | 2008年 / 10卷 / 2期

关键词：

Schizophrenia; Bipolar Disorder; Major Depressive Disorder; Down Syndrome; Major Depressive Disorder;

D O I：

10.1007/s11920-008-0025-2

中图分类号：

学科分类号：

摘要：

Chromosomal abnormalities can be powerful tools to identify genes that influence disease risk. The study of a chromosome translocation that segregated with severe psychiatric illness in a large family led directly to the discovery of a gene disrupted by a chromosomal breakpoint. Disrupted-in-Schizophrenia-1 (DISC1) is now an important candidate risk gene for schizophrenia and affective disorders. We review the work that led up to this discovery and the evidence that it is important in the wider population with schizophrenia and affective disorders. We also discuss the latest findings on the neuronal functions of the protein DISC1 encoded by the gene. Copyright © 2008 by Current Medicine Group LLC.

引用

页码：140 / 147

页数：7

共 52 条

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