Relations between vegetable, fruit and micronutrient intake. Implications for odds ratios in a case-control study

被引：12

作者：

Negri E. ^{[1
]}

La Vecchia C. ^{[1
,2
]}

Franceschi S. ^{[3
]}

机构：

[1] Istituto di Ricerche Farmacologiche 'Mario Negri', Milano

[2] Instituto di Statistica Medica e Biometria, Università degli Studi di Milano, Milano

[3] Field and Intervention Studies Unit, International Agency for Research on Cancer, Lyon

来源：

European Journal of Clinical Nutrition | 2002年 / 56卷 / 2期

关键词：

Cancer; Case-control studies; Diet; Micronutrients;

D O I：

10.1038/sj.ejcn.1601317

中图分类号：

学科分类号：

摘要：

Objective: To investigate whether the protection observed for some micronutrients, such as beta-carotene, in several observational studies may simply reflect vegetable and fruit intake. Design: A case-control study conducted in Italy. Subjects: The subjects were 1225 colon cancer patients, 728 rectal cancer patients and 4154 hospital controls. Results: For the 16 micronutrients considered, the more closely a micronutrient was correlated with total vegetable and fruit intake, the more it appeared protective against colorectal cancer. Conclusion: When studying the effect of a nutrient on disease risk in an observational setting, its relation to other nutrients and foods must be taken into account. © 2002 Nature Publishing Group.

引用

页码：166 / 170

页数：4

共 25 条

[1]

Block G., Vitamin C and cancer prevention: The epidemiologic evidence, Am. J. Clin. Nutr., 53, pp. 270S-282S, (1991)

[2]

Breslow N.E., Day N.E., Statistical Methods in Cancer Research, 1, (1980)

[3]

Decarli A., Franceschi S., Ferraroni M., Gnagnarella P., Parpinel M.T., La Vecchia C., Negri E., Salvini S., Falcini F., Giacosa A., Validation of a food frequency questionnaire to assess dietary intakes in cancer studies in Italy: Results for specific nutrients, Ann. Epidemiol., 6, pp. 110-118, (1996)

[4]

Eberhardt M.V., Lee C.Y., Liu R.H., Antioxidant activity of fresh apples, Nature, 405, pp. 903-904, (2000)

[5]

Franceschi S., Barbone F., Negri E., Decarli A., Ferraroni M., Filiberti E., Giacosa A., Gnagnarella P., Nanni O., Salvini S., La Vecchia C., Reproducibility of an Italian food frequency questionnaire for cancer studies. Results for specific nutrients, Ann. Epidemiol., 5, pp. 69-75, (1995)

[6]

Franceschi S., Favero A., La Vecchia C., Negri E., Conti E., Montella M., Giacosa A., Nanni O., Decarli A., Food groups and risk of colorectal cancer in Italy, Int. J. Cancer, 72, pp. 56-61, (1997)

[7]

Franceschi S., La Vecchia C., Russo A., Favero A., Negri E., Conti E., Montella M., Filiberti R., Amadori D., Decarli A., Macronutrient intake and risk of colorectal cancer in Italy, Int. J. Cancer, 76, pp. 321-324, (1998)

[8]

Ghadirian P., Lacroix A., Maisonneuve P., Perret C., Potvin C., Gravel D., Bernard B., Boyle P., Nutritional factors and colon carcinoma: A case-control study involving French Canadians in Montreal, Quebec, Canada, Cancer, 80, pp. 858-864, (1997)

[9]

Hennekens C.H., Buring J.E., Manson J.E., Stampfer M., Rosner B., Cook N.R., Belanger C., LaMotte F., Gaziano J.M., Ridker P.M., Willett W., Peto R., Lack of effect of long-term supplementation with beta carotene on the incidence of malignant neoplasms and cardiovascular disease, New Engl. J. Med., 334, pp. 1145-1149, (1996)

[10]

Krinsky N.I., Effects of carotenoids in cellular and animal systems, Am. J. Clin. Nutr., 53, pp. 238S-246S, (1991)

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