Recent insights into HIV accessory proteins

被引：10

作者：

Jenny L. Anderson

Thomas J. Hope

机构：

[1] Dept. of Microbiology and Immunology, University of Illinois at Chicago, Chicago

来源：

Current Infectious Disease Reports | 2003年 / 5卷 / 5期

基金：

美国国家卫生研究院;

关键词：

Human Immunodeficiency Virus Type; Long Terminal Repeat; Restrictive Cell; Dileucine Motif; Viral Infectivity Factor;

D O I：

10.1007/s11908-003-0024-8

中图分类号：

学科分类号：

摘要：

HIV produces structural, regulatory, and accessory proteins during viral replication in host cells. The accessory proteins include Nef, viral infectivity factor (Vif), viral protein R, and viral protein U or viral protein X. Although these accessory proteins are generally dispensable for viral replication in vitro, they are essential for viral pathogenesis in vivo. Consequently, there has been much interest in understanding how these accessory proteins function because this research may yield new antiviral targets to curb HIV pathogenesis in vivo. Therefore, this review highlights recent advances in understanding the HIV accessory proteins and emphasizes breakthrough insights into the elusive Vif protein and potential new targets for therapeutic intervention. Copyright © 2003 by Current Science Inc.

引用

页码：439 / 450

页数：11

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