Recent advances in intestinal iron transport

被引：30

作者：

Anderson G.J. ^{[1
]}

Frazer D.M. ^{[1
]}

机构：

[1] Iron Metabolism Laboratory, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane

来源：

Current Gastroenterology Reports | 2005年 / 7卷 / 5期

关键词：

Iron Absorption; Hemochromatosis; Brush Border Membrane; Iron Loading; Hepcidin Level;

D O I：

10.1007/s11894-005-0005-1

中图分类号：

学科分类号：

摘要：

Our understanding of intestinal iron absorption and its regulation has expanded enormously in recent years. Dietary iron crosses the enterocyte brush border membrane through the transporter DMT1 after first being reduced by the ferric reductase Dcytb. The subsequent movement of iron across the basolateral membrane and into the circulation is mediated by ferroportin1 in conjunction with the iron oxidase hephaestin. The activity of ferroportin1 is controlled by the liver-derived peptide hepcidin, and the expression of hepcidin in turn is influenced by plasma transferrin saturation via a pathway that involves HFE, TfR2, and hemojuvelin. Future studies investigating how these molecules interact will provide a comprehensive understanding of this essential physiologic process. Copyright © 2005 by Current Science Inc.

引用

页码：365 / 372

页数：7

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