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Regulation of the immune response by macrophage migration inhibitory factor: biological and structural features
被引：71
作者：
Jürgen Bernhagen
Thierry Calandra
Richard Bucala
机构：
[1] Laboratory of Biochemistry,
[2] Interfacial Engineering,undefined
[3] University of Stuttgart,undefined
[4] Nobelstrasse 12,undefined
[5] D-70569 Stuttgart,undefined
[6] Germany,undefined
[7] Division of Infectious Diseases,undefined
[8] Department of Internal Medicine,undefined
[9] Centre Hopitalier Universitaire Vaudois,undefined
[10] CH-1011 Lausanne,undefined
[11] Switzerland,undefined
[12] The Picower Institute for Medical Research,undefined
[13] 350 Community Drive,undefined
[14] Manhasset,undefined
[15] NY 11030,undefined
[16] USA,undefined
来源：
Journal of Molecular Medicine
|
1998年
/
76卷
关键词：
Key words Macrophage migration inhibitory factor;
Cytokine;
Glucocorticoids;
Neuroendocrine;
Septic shock;
T cell;
Monocytes/macrophage;
Molecular structure;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The classical T cell cytokine macrophage migration inhibitory factor (MIF) has reemerged recently as a critical mediator of the host immune and stress response. MIF has been found to be a mediator of several diseases including gram-negative septic shock and delayed-type hypersensitivity reactions. Its immunological functions include the modulation of the host macrophage and T and B cell response. In contrast to other known cytokines, MIF production is induced rather than suppressed by glucocorticoids, and MIF has been found to override the immunosuppressive effects of glucocorticoids. Recently, elucidation of the three-dimensional structure of MIF revealed that MIF has a novel, unique cytokine structure. Here the biological role of MIF is reviewed in view of its distinct immunological and structural properties.
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页码：151 / 161
页数：10
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