Evaluation of dynamic studies of MR mammography for the diagnosis of intraductal lesions with nipple discharge

被引：12

作者：

Ishikawa T. ^{[1
]}

Momiyama N. ^{[1
]}

Hamaguchi Y. ^{[1
]}

Takeuchi M. ^{[2
]}

Iwasawa T. ^{[2
]}

Yoshida T. ^{[2
]}

Shimada H. ^{[1
]}

机构：

[1] Second Department of Surgery, Yokohama City University, Kanazawa-ku, Yokohama

[2] Department of Radiology, Yokohama City University, Yokohama

来源：

Breast Cancer | 2004年 / 11卷 / 3期

关键词：

Breast cancer; Ductography; MR mammography;

D O I：

10.1007/BF02984551

中图分类号：

学科分类号：

摘要：

Objectives: We assessed the utility of dynamic magnetic resonance imaging (MRI) in differentiating benign from malignant lesions of the breast and then applied MRI to diagnose intraductal breast tumors with nipple discharge. Methods: Gadolinium (Gd)-enhanced MR mammography was performed on 74 patients with breast tumors and 8 patients with nipple discharge. Results: The steepest slopes of the contrast medium uptake (S slope) s from time-intensity curves were significantly different between malignant and benign lesions. At S slope threshold of 0.95%/second, malignancy was predicted with a sensitivity and specificity of 75%. Six of 8 cases with nipple discharge were successfully identified by MR ductography by injecting Gd-DTPA into discharging ducts. Among them, 2 non-invasive ductal carcinomas were differentiated from benign lesions by the S slope value. Conclusions: Dynamic MR mammography is an useful modality for differentiating breast lesions and has potential for evaluating intraductal lesions with nipple discharge.

引用

页码：288 / 294

页数：6

共 19 条

[1]

Buadu L.D., Murakami J., Murayama S., Hashiguchi N., Sakai S., Masuda K., Toyoshima S., Kuroki S., Ohno S., Breast lesions: Correlation of contrast medium enhancement patterns on MR images with histopathologic findings and tumor angiogenesis, Radiology, 200, 3, pp. 639-649, (1996)

[2]

Boetes C., Barentsz J.O., Mus R.D., Sluis R.F., Ljto E., Jhcl H., Holland H., Shj R., MR characterization of suspicious breast lesions with a gadolinium-enhanced turboFLASH subtraction technique, Radiology, 193, pp. 777-781, (1994)

[3]

Davis P.L., McCarty Jr. K.S., Sensitivity of enhanced MRI for the detection of breast cancer: New, multicentric, residual, and recurrent, Eur Radiol, 7, SUPPL. 5, pp. 289-298, (1997)

[4]

Davis P.L., Staiger M.J., Harris K.B., Ganott M.A., Klementaviciene J., McCarty Jr. K.S., Tobon H., Breast cancer measurements with magnetic resonance imaging, ultrasonography, and mammography, Breast Cancer Research and Treatment, 37, 1, pp. 1-9, (1996)

[5]

Stomper P.C., Herman S., Klippenstein D.L., Winston J.S., Edge S.B., Arredondo M.A., Mazurchunk R.V., Blumenson L.E., Suspect breast lesions: Findings at dynamic gadolinium-enhanced MR imaging correlated with mammographic and pathologic features, Radiology, 197, pp. 378-395, (1995)

[6]

Fobben E.S., Rubin C.Z., Kalisher L., Dembner A.G., Seltzer M.H., Santoro E.J., Breast MR imaging with commercially available techniques: Radiologic-pathologic correlation, Radiology, 196, pp. 143-152, (1995)

[7]

Stomper P.C., Herman S., Klippenstein D.L., Winston J.S., Budnick R.M., Stewart C.C., Invasive breast carcinoma: Analysis of dynamic magnetic resonance imaging enhancement features and cell proliferation activity determined by DNA S-phase percentage, Cancer, 77, pp. 1844-1849, (1996)

[8]

Dawes L.G., Bowen C., Venta L.A., Morrow M., Ductography for nipple discharge: No replacement for ductal excision, Surgery, 124, 4, pp. 685-691, (1998)

[9]

Buckley D.L., Drew P.J., Mussurakis S., Monson J.R., Horsman A., Microvessel density of invasive breast cancer assessed by dynamic Gd-DTPA enhanced MRI, J Magn Reson Imaging, 7, pp. 461-464, (1997)

[10]

Furman H.E., Margalit R., Grobgeld D., Degani H., Dynamic contrast-enhanced magnetic resonance imaging reveals stress-induced angiogenesis in MCF7 human breast tumors, Proc Natl Acad Sci USA, 93, pp. 6247-6251, (1996)

← 1 2 →