Impact of antibiotic resistance on the treatment of gram-negative sepsis

被引：4

作者：

Baden L.R. ^{[1
]}

Eisenstein B.I. ^{[2
]}

机构：

[1] Division of Infectious Disease, Brigham and Women’s Hospital, and Harvard Medical School, PBB-A4, 15 Francis Street, Boston, 02115, MA

[2] Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, 02115, MA

来源：

Current Infectious Disease Reports | 2000年 / 2卷 / 5期

关键词：

Diagn Microbiol Infect; Lactam; National Nosocomial Infection Surveillance; National Nosocomial Infection Surveillance System; Resistant Organism;

D O I：

10.1007/s11908-000-0067-z

中图分类号：

学科分类号：

摘要：

Resistance among gram-negative organisms has greatly complicated the care of the septic patient. An understanding of the likely source of infection, the epidemiologic risk of the patient being exposed to an antibiotic-resistant organism, and the specific vulnerabilities of the host are essential to the proper selection of empiric antimicrobial therapy. In this report, we discuss the epidemiology, antibiotic resistance mechanisms, microbiology, treatment strategies, and diagnostic and therapeutic innovations in the approach to the septic patient. © 2000, Current Science Inc.

引用

页码：409 / 416

页数：7

共 43 条

[1]

Bone R.C., Grodzin C.J., Balk R.A., Sepsis: a new hypothesis for pathogenesis of the disease process, Chest, 112, pp. 235-243, (1997)

[2]

Ziegler E.J., Fisher C.J., Sprung C.L., Et al., Treatment of gramnegative bacteremia and septic shock with HA-1A human monoclonal antibody against endotoxin. A randomized, double-blind, placebo-controlled trial. The HA-1A Sepsis Study Group, N Engl J Med, 324, pp. 429-436, (1991)

[3]

Eisenstein B.I., Zaleznik D.F., Enterobacteriaceae, Principles and Practice of Infectious Diseases, pp. 2294-2310, (1999)

[4]

Gold H.S., Moellering R.C., Antimicrobial-drug resistance, N Engl J Med, 335, pp. 1445-1453, (1996)

[5]

National Nosocomial Infections Surveillance (NNIS) System Report, Data, Summary from October 1986–April 1998, pp. 1-25, (1998)

[6]

Miller Y.W., Eady E.A., Lacey R.W., Et al., Sequential antibiotic therapy for acne promotes the carriage of resistant staphylococci on the skin of contacts, J Antimicrob Chemother, 38, pp. 829-837, (1996)

[7]

Levy S.B., Multidrug resistance--a sign of the times [editorial

[8]

comment], N Engl J Med, 338, pp. 1376-1378, (1998)

[9]

Endtz H.P., Ruijs G.J., van Klingeren B., Et al., Quinolone resistance in Campylobacter isolated from man and poultry following the introduction of fluoroquinolones in veterinary medicine, J Antimicrob Chemother, 27, pp. 199-208, (1991)

[10]

Glynn M.K., Bopp C., Dewitt W., Et al., Emergence of multidrugresistant Salmonella enterica serotype typhimurium DT104 infections in the United States, N Engl J Med, 338, pp. 1333-1338, (1998)

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