White matter changes on magnetic resonance imaging following whole-brain radiotherapy for brain metastases

被引：32

作者：

Fujii O. ^{[1
]}

Tsujino K. ^{[1
]}

Soejima T. ^{[1
]}

Yoden E. ^{[1
]}

Ichimiya Y. ^{[1
]}

Sugimura K. ^{[2
]}

机构：

[1] Department of Radiation Oncology, Hyogo Medical Center for Adults, Akashi 673-8558

[2] Division of Radiology, Kobe University Graduate School of Medicine, Kobe

来源：

Radiation Medicine | 2006年 / 24卷 / 5期

关键词：

Abnormalities; Brain; Magnetic resonance imaging; Metastases; Radiation-induced;

D O I：

10.1007/s11604-006-0039-9

中图分类号：

学科分类号：

摘要：

Purpose. The purpose of this study was to evaluate white matter (WM) abnormalities induced by WBRT. Materials and methods. Twenty-four patients (11 men and 13 women; age range 38-74 years, median 60 years) who survived for more than 1 year after completion of WBRT (radiation dose range 30-40Gy, median 35Gy) at our institution between January 2000 and June 2003 were followed up with magnetic resonance (MR) scans for 11-51 months (median 19 months). We evaluated WM changes attributable to WBRT as grade 0-6 and assessed possible contributing factors by statistical analysis. Results. WM changes were found in 20 patients: Eight were assessed as grade 2, three as grade 3, and nine as grade 5. In total, 12 patients developed grade 3 or higher WM changes. Age (<60 vs ≥60 years), sex, radiation dose (≤35 vs >35 Gy), chemotherapy (with CDDP vs without CDDP), biologically effective dose (≤120 vs >120Gy1), and head width (<16.3 vs ≥16.3cm) were found not to be relevant to the incidence or severity of the WM changes. Conclusion. Long-term survivors who have undergone WBRT may have a higher incidence of WM abnormalities. © Japan Radiological Society 2006.

引用

页码：345 / 350

页数：5

共 23 条

[1]

Burger P.C., Mahley M.S., Dudka L., Vogel F.S., The morphologic effects of radiation administered therapeutically for intracranial gliomas: A postmortem study of 25 cases, Cancer, 44, pp. 1256-1272, (1979)

[2]

Burger P., Boyko O.B., Radiation injury to the nervous system, The Pathology of Central Nervous System Radiation Injury, pp. 191-208, (1991)

[3]

Caveness W.F., Experimental observations: Delayed necrosis in normal monkey brain, Radiation Damage to the Nervous System, pp. 1-38, (1980)

[4]

Hopewell J.W., Late radiation damage to the central nervous system: A radiobiological interpretation, Neuropathol Appl Neurobiol, 5, pp. 329-343, (1979)

[5]

Martins A.N., Johnston J.S., Henry J.M., Stoffel T.J., DiChiro G., Delayed radiation necrosis of the brain, J Neurosurg, 47, pp. 336-345, (1977)

[6]

Tiller-Borcich J.K., Fike J.R., Phillips T.L., Davis R.L., Pathology of delayed radiation brain damage: An experimental canine model, Radiat Res, 110, pp. 161-172, (1987)

[7]

Curnes J.T., Laster D.W., Ball M.R., Moody D.M., Witcofski R.L., Magnetic resonance imaging of radiation injury to the brain, AJNR Am J Neuroradiol, 7, pp. 389-394, (1986)

[8]

Curran W.J., Hecht-Leavitt C., Shut L., Zimmerman R.A., Nelson D.F., Magnetic resonance imaging of cranial radiation lesions, Int J Radiat Oncol Biol Phys, 13, pp. 1093-1098, (1987)

[9]

Dooms G.C., Hecht S., Brant-Zawadzki M., Berthiaume Y., Norman D., Newton T.H., Brain radiation lesions: MR imaging, Radiology, 158, pp. 149-155, (1986)

[10]

Tsuruda J.S., Kortman K.E., Bradley W.G., Wheeler D.C., Dalsem W.V., Bradley T.P., Radiation effects on cerebral white matter

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