Calcium Receptor and Regulation of Parathyroid Hormone Secretion

被引：63

作者：

Brown E.M. ^{[1
,2
]}

机构：

[1] Endocr.-Hypertension Div. Memb. B., Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115

[2] Endocrine-Hypertension Division, Brigham and Women's Hospital, Boston, MA 02115

来源：

Reviews in Endocrine and Metabolic Disorders | 2000年 / 1卷 / 4期

基金：

美国国家卫生研究院;

关键词：

Calcium receptor; Parathyroid cell; PTH; Second messengers; Secretion; Signal transduction;

D O I：

10.1023/A:1026570518919

中图分类号：

学科分类号：

摘要：

The cloning of the CaR has made it possible to show definitively that the CaR is a critical mediator of the inhibitory effect of high Ca2+ on PTH secretion and parathyroid cellular proliferation. The receptor may also mediate the suppressive action of high Ca2+o on PTH gene expression, while its involvment in several other known actions of Ca2+o on parathyroid function remain to be examined. Alterations in CaR expression and/or function are clearly involved in hyper- and hypocalcemic disorders caused by inactivating or activating CaR mutations, respectively, and could contribute to the deranged Ca2+o-sensing in primary and uremic secondary HPT. Finally, CaR activators offer promise as the first truly effective mode of medical therapy for these latter two conditions.

引用

页码：307 / 315

页数：8

共 47 条

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[2]

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[3]

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[4]

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[7]

Chattopadhyay N., Cheng I., Rogers K., Riccardi D., Hall A., Diaz R., Hebert S.C., Soybel D.I., Brown E.M., Identification and localization of extracellular Ca(2+)-sensing receptor in rat intestine, Am J Physiol, 274, (1998)

[8]

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