Sertraline in the treatment of premature ejaculation: A double-blind placebo controlled study

被引:37
作者
Biri H. [1 ]
Isen K. [1 ]
Sinik Z. [1 ]
Onaran M. [1 ]
Küpeli B. [1 ]
Bozkirli I. [1 ]
机构
[1] Department of Urology, Medical School of Gazi University, Ankara
关键词
Fluoxetine; Paroxetine; Sertraline; Serotonin Reuptake; International Urology;
D O I
10.1007/BF02550555
中图分类号
学科分类号
摘要
This study investigated the efficacy and the adverse effects of sertraline in the treatment of premature ejaculation (PE). Thirty-seven patients with PE were randomly assigned to receive either sertraline or a placebo. Of them 22 were given 50 mg of sertraline per day and the other 15 patients were given an identical placebo one per day. After 4 weeks, the latency to ejaculation in the sertraline group was found to be significantly longer than that of the placebo group (p<0.01). None of the patients discontinued therapy due to adverse effects. These results indicate that sertraline is an effective therapy for PE.
引用
收藏
页码:611 / 615
页数:4
相关论文
共 18 条
[1]  
Derogatis, L.R., Aetiologic factors in premature ejaculation (1980) Med. Aspects Hum. Sexuality, 14, p. 1168
[2]  
Schapiro, B., Premature ejaculation: A review of 1130 cases (1943) J. Urol., 50, p. 374
[3]  
Rouleu, J.L., Sex therapy and disorders of ejaculation (1993) Acta Urol. Belg., 23, p. 281
[4]  
Bitran, D., Hull, E.M., Pharmacological analysis of male rat sexual behavior (1987) Neurosci. Biobehav. Rev., 11, p. 365
[5]  
Stahl, S.M., Serotonergic mechanisms and the new antidepressants (1993) Psychol. Med., 23, p. 281
[6]  
Mcintosh, T.K., Barfield, R.J., Brain monoaminergic control of male reproductive behavior. I: Serotonin and the post-ejaculatory refractory period (1984) Behav. Brain Res., 12, p. 255
[7]  
Heym, J., Koe, B.K., Pharmacology of sertraline: A review (1988) Psychiatry, 49 (SUPPL.), p. 40
[8]  
Guthrie, S.K., Sertraline: A new specific serotonin reuptake blocker (1991) Ann. Pharmacother., 25, p. 952
[9]  
Mendels, J., Camera, A., Sikes, C., Sertraline treatment for premature ejaculation (1995) J. Clin. Psychopharmacol., 15, p. 341
[10]  
Masters, W.H., Johnson, V.E., (1970) Human Sexual Inadequacy, , Little, Brown &, Co., Boston