Biomechanics of the aging spine

被引:54
作者
Stephen J. Ferguson
Thomas Steffen
机构
[1] University of Berne,M.E. Müller Research Center for Orthopaedic Surgery, Institute for Surgical Technology and Biomechanics
[2] McGill University,Orthopaedic Research Laboratory
来源
European Spine Journal | 2003年 / 12卷
关键词
Aging spine; Biomechanics; Osteoporosis; Vertebral endplate; Disc degeneration;
D O I
暂无
中图分类号
学科分类号
摘要
The human spine is composed of highly specific tissues and structures, which together provide the extensive range of motion and considerable load carrying capacity required for the physical activities of daily life. Alterations to the form and composition of the individual structures of the spine with increasing age can increase the risk of injury and can have a profound influence on the quality of life. Cancellous bone forms the structural framework of the vertebral body. Individual trabeculae are oriented along the paths of principal forces and play a crucial role in the transfer of the predominantly compressive forces along the spine. Age-related changes to the cancellous core of the vertebra includes a loss of bone mineral density, as well as morphological changes including trabecular thinning, increased intratrabecular spacing, and loss of connectivity between trabeculae. Material and morphological changes may lead to an increased risk of vertebral fracture. The vertebral endplate serves the dual role of containing the adjacent disc and evenly distributing applied loads to the underlying cancellous bone and the cortex of the vertebra. With aging, thinning of the endplate, and loss of bone mineral density increases the risk of endplate fracture. Ossification of the endplate may have consequences for the nutritional supply and hydration of the intervertebral disc. The healthy intervertebral disc provides mobility to the spine and transfers load via hydrostatic pressurization of the hydrated nucleus pulposus. Changes to the tissue properties of the disc, including dehydration and reorganization of the nucleus and stiffening of the annulus fibrosus, markedly alter the mechanics of load transfer in the spine. There is no direct correlation between degenerative changes to the disc and to the adjacent vertebral bodies. Furthermore, advancing age is not the sole factor in the degeneration of the spine. Further study is crucial for understanding the unique biomechanical function of the aging spine.
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页码:S97 / S103
相关论文
共 34 条
[1]
Acaroglu undefined(1995)undefined Spine 20 2690-undefined
[2]
Adams undefined(1996)undefined J Bone Joint Surg Br 78 965-undefined
[3]
Ayotte undefined(2000)undefined J Biomech Eng 122 587-undefined
[4]
Brinckmann undefined(1989)undefined Spine 14 606-undefined
[5]
Cummings undefined(1995)undefined Am J Med 98 24S-undefined
[6]
Dai undefined(1998)undefined Eur Spine J 7 40-undefined
[7]
Ebara undefined(1996)undefined Spine 21 452-undefined
[8]
Grant undefined(2001)undefined Spine 26 889-undefined
[9]
Grant undefined(2002)undefined J Orthop Res 20 1115-undefined
[10]
Hansson undefined(1987)undefined J Orthop Res 5 479-undefined