Galectin-3 in cardiac remodeling and heart failure

被引：202

作者：

De Boer R.A. ^{[1
]}

Yu L. ^{[1
]}

Van Veldhuisen D.J. ^{[1
]}

机构：

[1] Department of Cardiology, Division of Experimental Cardiology, University Medical Center Groningen, Groningen 9700 RB

来源：

Current Heart Failure Reports | 2010年 / 7卷 / 1期

关键词：

Biomarkers; Fibrosis; Galectin; 3; Heart failure; Macrophages; Prognosis; Renin-angiotensin system;

D O I：

10.1007/s11897-010-0004-x

中图分类号：

学科分类号：

摘要：

Galectin-3 is a member of the galectin family, which consists of animal lectins that bind β-galactosides. Recently, a role for galectin-3 in the pathophysiology of heart failure has been suggested. It was observed that galectin-3 is specifically upregulated in decompensated heart failure compared with compensated heart failure in animal models of heart failure. This has been associated with activation of fibroblasts and macrophages, which are a hallmark of cardiac remodeling. Therefore, galectin-3 may be a culprit biomarker in heart failure. Initial clinical observations indicate that galectin-3 may be a useful biomarker for decompensated heart failure, with incremental value over well-used "pressure-dependent" biomarkers, such as B-type natriuretic peptide. Future studies should focus on galectin-3 biology to better address the usefulness of galectin-3 as a biomarker and probe the usefulness of anti-galectin-3 therapy in treating heart failure. © 2010 The Author(s).

引用

页码：1 / 8

页数：7

共 47 条

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