Treatment of chronic hepatitis C in nonresponders to interferon monotherapy.

被引：3

作者：

Kwo P.Y. ^{[1
]}

机构：

[1] Division of Gastroenterology/Hepatology, Indiana University School of Medicine, IB 424, 975 West Walnut Street, Indianapolis, 46202-5121, IN

来源：

Current Gastroenterology Reports | 2000年 / 2卷 / 1期

关键词：

Sustained Virologic Response; Virologic Response; Sustained Virologic Response Rate; Hepatic Iron; Interferon Monotherapy;

D O I：

10.1007/s11894-000-0046-4

中图分类号：

学科分类号：

摘要：

Sixty percent of patients fail to respond to interferon monotherapy. African-Americans with hepatitis C appear to respond less well to interferon monotherapy. Retreatment with a higher dose of consensus interferon for 48 weeks has led to a sustained virologic response rate of 13%. As a group, interferon nonresponders who breakthrough while on interferon monotherapy seem to have a more favorable response rate to a repeat course of treatment. Retreatment with interferon and ribavirin for 6 months in nonresponders led to a sustained virologic response rate of 21%. Preliminary results from two trials in the United States demonstrate similar treatment efficacy. There is now evidence that maintenance interferon therapy may also be beneficial in interferon monotherapy nonresponders.

引用

页码：11 / 17

页数：6

共 61 条

[1]

Kageyama F(1998)Failure to respond to interferon-alpha 2a therapy is associated with increased hepatic iron levels in patients with chronic hepatitis C Biol Trace Elem Res 64 185-196

[2]

Kobayashi Y(1999)A pilot study of iron depletion as adjuvant therapy in chronic hepatitis C patients not responding to interferon Am J Gastroenterol 94 1696-1698

[3]

Murohisa G(1996)Retreatment of hepatitis C interferon non-responders with larger doses of interferon with and without phlebotomy Hepatogastroenterology 43 1557-1561

[4]

Guyader D(1997)Effect of iron depletion on long-term response to interferon-alpha in patients with chronic hepatitis C who previously did not respond to interferon therapy Am J Gastroenterol 92 1831-1834

[5]

Boucher E(1999)Racial differences in responses to therapy with interferon in chronic hepatitis C Hepatology 30 787-793

[6]

Andre P(1999)Standards of treatment in chronic hepatitis C Semin Liver Dis 19 35-47

[7]

Van Thiel DH(1997)Therapy of hepatitis C: re-treatment with alpha interferon Hepatology 26 137S-142S

[8]

Friedlander L(1998)Re-treatment of chronic hepatitis C with consensus interferon Hepatology 27 1136-1143

[9]

Molloy PJ(1998)Re-treatment with interferon alfa of patients with chronic hepatitis C Hepatology 27 1144-1148

[10]

Tsai NC(1999)Chronic hepatitis C virus patients with breakthroughs during interferon treatment can successfully be retreated with consensus interferon Hepatology 30 562-566

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