T cells, cytokines, and autoantigens in multiple sclerosis.

被引：22

作者：

Gran B. ^{[1
]}

Rostami A. ^{[1
]}

机构：

[1] Department of Neurology, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, 19104-4283, PA

来源：

Current Neurology and Neuroscience Reports | 2001年 / 1卷 / 3期

基金：

美国国家卫生研究院;

关键词：

Multiple Sclerosis; Experimental Autoimmune Encephalomyelitis; Multiple Sclerosis Patient; Myelin Basic Protein; Molecular Mimicry;

D O I：

10.1007/s11910-001-0029-3

中图分类号：

学科分类号：

摘要：

In multiple sclerosis (MS), inflammatory demyelination in the central nervous system is thought to be initiated by T cells that recognize myelin antigens. T cells are the main regulators of acquired immunity and are involved in the pathogenesis of several organ-specific autoimmune diseases. This review provides an overview of recent studies on the role of T cells in autoimmune demyelination. Because autoreactive T cells are normally present in the mature repertoire of T cells in the blood and lymphoid organs of MS patients, but also in normal controls, particular attention is devoted to the mechanisms of activation and the functional phenotype of such T cells in patients with MS. The role of cytokines as effector molecules and the main candidate antigens are also discussed.

引用

页码：263 / 270

页数：7

共 175 条

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