Complement- induced impairment of the innate immune system during sepsis

被引：12

作者：

Albrecht E.A. ^{[1
]}

Ward P.A. ^{[1
]}

机构：

[1] Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109-0602

来源：

Current Infectious Disease Reports | 2005年 / 7卷 / 5期

关键词：

Chronic Obstructive Pulmonary Disease; Innate Immune System; Abdominal Aortic Aneurysm; Membrane Attack Complex; Glomerular Epithelial Cell;

D O I：

10.1007/s11908-005-0008-y

中图分类号：

学科分类号：

摘要：

The complement system is an integral part of innate immunity and is chiefly responsible for controlling bacterial infections, especially those involving gram-negative organisms. To accomplish this task, serum proteins engage in a series of enzymatic cascades. The cleaved proteins assemble pores on membranous structures, which lead to cell lysis. During this process, powerful inflammatory mediators are produced, including the anaphylatoxins, C5a, C3a, and the membrane attack complex (MAC). Under systemic inflammatory conditions, an overactive complement system may compromise the effectiveness of innate immunity. We review the detrimental effects that are caused by uncontrolled complement activation during sepsis. Copyright © 2005 by Current Science Inc.

引用

页码：349 / 354

页数：5

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