Genetic polymorphism and cancer risk.

被引：37

作者：

Clapper M.L. ^{[1
]}

机构：

[1] Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, 19111, PA

来源：

Current Oncology Reports | 2000年 / 2卷 / 3期

基金：

美国国家卫生研究院;

关键词：

Cancer Risk; Breast Cancer Risk; Cancer Susceptibility; Oral Squamous Cell Carcinoma; Lung Cancer Risk;

D O I：

10.1007/s11912-000-0075-z

中图分类号：

学科分类号：

摘要：

Inter-individual variability in carcinogen metabolism has been attributed in part to the polymorphic expression of several phase I and II detoxification enzymes. The role of these genetic polymorphisms in cancer susceptibility has been most extensively evaluated for isozymes of cytochrome P450 (CYP1A1, CYP2D6, and CYP2E1), N-acetyltransferase (NAT1 and NAT2), glutathione S-transferase (GSTM1, GSTT1, and GSTP1), microsomal epoxide hydrolase, and NAD(P)H:quinone oxidoreductase. Our understanding of the genetic basis of cancer risk has been enhanced most recently by establishment of genotype-phenotype correlations in humans and identification of numerous diverse factors, both genetic and environmental, that can modify risk.

引用

页码：251 / 256

页数：5

共 115 条

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