Heredity and the autonomic nervous system in human hypertension

被引：54

作者：

O'Connor D.T. ^{[1
]}

Insel P.A. ^{[1
]}

Ziegler M.G. ^{[1
]}

Hook V.Y. ^{[1
]}

Smith D.W. ^{[1
]}

Hamilton B.A. ^{[1
]}

Taylor P.W. ^{[1
]}

Parmer R.J. ^{[1
]}

机构：

[1] Department of Medicine and Pharmacology, Center for Molecular Genetics, University of California, San Diego, San Diego, CA 92161

来源：

Current Hypertension Reports | 2000年 / 2卷 / 1期

关键词：

Essential Hypertension; Autonomic Nervous System; Yohimbine; Intermediate Phenotype; Baroreflex Sensitivity;

D O I：

10.1007/s11906-000-0053-8

中图分类号：

学科分类号：

摘要：

Because the complex phenotype of human hypertension is at least in part genetically determined, how individual genes ultimately contribute to the disease is not well understood. By contrast, intermediate phenotypes are traits associated with complex disease, but which may display simpler genetic properties such as greater heritability, more consistent and earlier penetrance and bimodality, and may suggest particular candidate susceptibility genes. Because autonomic nervous system activity is altered in hypertension, we examined biochemical, physiologic, and pharmacologic autonomic traits that fulfill at least some of these properties. Such biochemical, physiologic, or pharmacologic autonomic traits may be especially valuable as phenotypic anchor points in linkage or association studies probing the genetic basis of human hypertension. Copyright © 2000 by Current Science Inc.

引用

页码：16 / 22

页数：6

共 77 条

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