Systolic versus diastolic blood pressure versus pulse pressure

被引：20

作者：

White W.B. ^{[1
]}

机构：

[1] Section of Hypertension and Clinical Pharmacology, University of Connecticut School of Medicine, Farmington, CT 06030-3940

来源：

Current Cardiology Reports | 2002年 / 4卷 / 6期

关键词：

Pulse Pressure; Systolic Hypertension; Eplerenone; Fosinopril; Isolate Systolic Hypertension;

D O I：

10.1007/s11886-002-0107-4

中图分类号：

学科分类号：

摘要：

Elevation of systolic blood pressure (BP) has been recognized as an independent risk factor that far exceeds the risk associated with an elevated diastolic BP in older patients with hypertension. Isolated systolic hypertension (ISH) is a disorder typically defined when the systolic BP is greater than 140 mm Hg but with diastolic BP below 90 mm Hg. Pulse pressure (the difference between systolic and diastolic pressure) has recently become an active area of discussion in the literature as an independent factor of cardiovascular risk. An increased pulse pressure nearly always indicates reduced vascular compliance of large arteries and, by definition, is always increased in patients with isolated systolic hypertension. Although the evidence that a widened pulse pressure is an independent marker of cardiovascular risk is quite well established, therapeutic morbidity and mortality studies in ISH have focused on reductions in systolic pressure. At the present time, outcomes data have not been well established for reductions in pulse pressure in older patients with hypertension. Copyright © 2002 by Current Science Inc.

引用

页码：463 / 467

页数：4

共 30 条

[1]

Stamler J., Stamler R., Neaton J., Blood pressure, systolic and diastolic, and cardiovascular risks: Us population data, Arch Intern Med, 153, pp. 598-615, (1993)

[2]

The 6th report of the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure, Arch Intern Med, 157, pp. 2413-2446, (1997)

[3]

Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension: Final results of the systolic hypertension in the elderly program (SHEP), JAMA, 265, pp. 3255-3264, (1991)

[4]

Staessen J.A., Fagard R., Thijs L., Et al., Randomised double-blind comparison of placebo and active treatment for older patients with isolated systolic hypertension, Lancet, 350, pp. 757-764, (1997)

[5]

Vardan S., Mookherjee S., Perspective on isolated systolic hypertension in elderly patients, Arch Fam Med, 9, pp. 319-323, (2000)

[6]

White W.B., Benefits of antihypertensive therapy in older patients with hypertension, Arch Intern Med, 160, pp. 149-150, (2000)

[7]

Smulyan H., Safar M.E., The diastolic blood pressure in systolic hypertension, Ann Intern Med, 32, pp. 233-237, (2000)

[8]

Domanski M.J., Davis B.R., Pfeffer M.A., Et al., Isolated systolic hypertension: Prognostic information provided by pulse pressure, Hypertension, 34, pp. 375-380, (1999)

[9]

Franklin S.S., Sutton-Tyrell K., Belle S.H., Et al., The importance of pulsatile components of hypertension in predicting carotid stenosis in older adults, J Hypertens, 15, pp. 1143-1150, (1997)

[10]

Vaccarino V., Holford T.R., Krumholz H.M., Pulse pressure and risk for myocardial infarction and heart failure in the elderly, J Am Coll Cardiol, 36, pp. 130-136, (2000)

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