Novel humanized murine models for HIV research

被引：54

作者：

Denton P.W. ^{[1
]}

Garcia J.V. ^{[1
]}

机构：

[1] Department of Internal Medicine, Division of Infectious Diseases, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390-9113

来源：

Current HIV/AIDS Reports | 2009年 / 6卷 / 1期

基金：

美国国家卫生研究院;

关键词：

Humanize Mouse; Human Fetal Liver; Major Histocompatability Complex; Human Thymocyte; Vaginal Transmission;

D O I：

10.1007/s11904-009-0003-2

中图分类号：

学科分类号：

摘要：

There are few models in which HIV pathogenesis, particularly gut-associated lymphoid tissue CD4 + T-cell depletion, can be studied and in which potential clinical interventions against HIV disease can be evaluated. HIV cannot be studied in normal mice due to the limited species tropism of the virus. Through the pioneering efforts of many investigators, humanized mice are now routinely used to rapidly advance HIV research. It is important to recognize that not all humanized murine models are equal, and their strengths and weaknesses must be taken into consideration to obtain information that is most relevant to the human condition. This review distinguishes the major humanization protocols and highlights each model's recent contributions to HIV research, including mucosal transmission, gut-associated lymphoid tissue pathogenesis, and the evaluation of novel therapeutic and prevention approaches to potentially treat HIV disease and prevent the further spread of AIDS. Copyright © 2009 by Current Medicine Group LLC.

引用

页码：13 / 19

页数：6

共 42 条

[1] Mosier D.E., Gulizia R.J., Baird S.M., Wilson D.B., Transfer of a functional human immune system to mice with severe combined immunodeficiency, Nature, 335, pp. 256-259, (1988)
[2] Baumann J.G., Unutmaz D., Miller M.D., Et al., Murine T cells potently restrict human immunodeficiency virus infection, J Virol, 78, pp. 12537-12547, (2004)
[3] McCune J., Kaneshima H., Krowka J., Et al., The SCID-hu mouse: A small animal model for HIV infection and pathogenesis, Annu Rev Immunol, 9, pp. 399-429, (1991)
[4] McCune J.M., Kaneshima H., Lieberman M., Et al., The SCID-hu mouse: Current status and potential applications, Curr Top Microbiol Immunol, 152, pp. 183-193, (1989)
[5] Brenchley J.M., Price D.A., Douek D.C., HIV disease: Fallout from a mucosal catastrophe?, Nat Immunol, 7, pp. 235-239, (2006)
[6] Dandekar S., Pathogenesis of HIV in the gastrointestinal tract, Curr HIV/AIDS Rep, 4, pp. 10-15, (2007)
[7] Shultz L.D., Ishikawa F., Greiner D.L., Humanized mice in translational biomedical research, Nat Rev Immunol, 7, pp. 118-130, (2007)
[8] Garcia S., Dadaglio G., Gougeon M.L., Limits of the human-PBL-SCID mice model: Severe restriction of the V beta T-cell repertoire of engrafted human T cells, Blood, 89, pp. 329-336, (1997)
[9] Saxon A., Macy E., Denis K., Et al., Limited B cell repertoire in severe combined immunodeficient mice engrafted with peripheral blood mononuclear cells derived from immunodeficient or normal humans, J Clin Invest, 87, pp. 658-665, (1991)
[10] McCune J.M., Namikawa R., Kaneshima H., Et al., The SCID-hu mouse: Murine model for the analysis of human hematolymphoid differentiation and function, Science, 241, pp. 1632-1639, (1988)

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