Functional serotonin 5-HTTLPR polymorphism is a risk factor for migraine with aura

被引：41

作者：

Borroni B. ^{[1
]}

Brambilla C. ^{[1
]}

Liberini P. ^{[1
]}

Rao R. ^{[1
]}

Archetti S. ^{[1
]}

Gipponi S. ^{[1
]}

Dalla Volta G. ^{[2
]}

Padovani A. ^{[1
]}

机构：

[1] Department of Neurology, University of Brescia, I-25100 Brescia

[2] Headache Centre, Città di Brescia Hospital, Brescia

来源：

The Journal of Headache and Pain | 2005年 / 6卷 / 4期

关键词：

5-HTTLPR; Aura; Migraine; Polymorphism; Serotonin;

D O I：

10.1007/s10194-005-0179-9

中图分类号：

学科分类号：

摘要：

In the present work, we report that the functional serotonin transporter gene promoter (5-HTTLPR) polymorphism is involved in migraine pathogenesis. The distribution of 5-HTTLPR genotypes was significantly different in MA patients (S/S vs. S/L vs. L/L=32.7 vs. 42.3 vs. 25.0%), MO patients (18.5 vs. 39.1 vs. 42.4%) and CON (18.0 vs. 51.3 vs. 30.7%; chi-square test, p <0.05). In 5-HTTLPR S/S carriers, the odds ratio for MA risk was 2.60 (95% confidence interval [95%CI]=1.75-3.85) compared to CON, and it was 2.14 (95%CI=1.42-3.21) compared to MO. These data provide a further insight on the complex genotype-phenotype relationship involved in MA pathogenesis, and might eventually result in new and individualised prognostic and therapeutic measures. © Springer-Verlag Italia 2005.

引用

页码：182 / 184

页数：2

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