Lipoprotein profile in older patients with vascular dementia and Alzheimer's disease

被引：22

作者：

Zuliani G. ^{[1
,2
]}

Ble A. ^{[1
]}

Zanca R. ^{[1
]}

Munari M.R. ^{[3
]}

Zurlo A. ^{[2
,4
]}

Vavalle C. ^{[1
]}

Atti A.R. ^{[1
]}

Fellin R. ^{[1
,2
]}

机构：

[1] Dept. of Clin. and Exp. Medicine, Section of Internal Medicine II, University of Ferrara

[2] Ctro. E. Malattia Alzheimer-Perusini, Ferrara

[3] Long Term Division, Ca' Foncello Hospital, Treviso

[4] Geriatric Division, S. Anna Hospital, Ferrara

来源：

BMC Geriatrics | / 1卷 / 1期

关键词：

Vascular Dementia; Serum Albumin Level; Small Vessel Disease; Lipoprotein Profile; Plasma Lipid Level;

D O I：

10.1186/1471-2318-1-5

中图分类号：

学科分类号：

摘要：

Background: Some alterations of the lipoprotein profile have been associated with cerebrovascular disease. Recently, it has been suggested that cerebrovascular disease might play a role in the pathogenesis of both vascular dementia (VD) and Alzheimer's disease (AD). Nevertheless, the possible association of dyslipidemias with VD or AD is still a controversial issue. Methods: We investigated the lipoprotein profile in 100 older patients with vascular dementia (VD; n°: 60) or Late Onset Alzheimer's Disease (LOAD; n°: 40). The patients were compared with 54 community dwelling non-demented older controls. Results: After adjustment for functional status, blood sedimentation rate, and serum albumin levels, no differences in lipoprotein profile emerged between the three groups, with the exception of HDL-C that was lower in VD compared with controls. Low HDL-C (< 45 mg/dL) was associated with VD (O.R.: 6.52, C.I. 95%: 1.42-30.70 vs controls, and 4.31, C.I. 95%: 0.93-19.82 vs LOAD), after multivariate adjustment. No differences in plasma lipid levels emerged between the three groups after stratification for apo E4 genotype. Conclusions: In this cross-sectional study low HDL-C levels are associated with VD, but not with LOAD, in a sample of older subjects.

引用

页码：1 / 5

页数：4

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