Mammographic features associated with interval breast cancers in screening programs

被引：42

作者：

Boyd N.F. ^{[1
,5
]}

Huszti E. ^{[1
,5
]}

Melnichouk O. ^{[1
,5
]}

Martin L.J. ^{[1
,5
]}

Hislop G. ^{[2
]}

Chiarelli A. ^{[3
]}

Yaffe M.J. ^{[4
]}

Minkin S. ^{[5
]}

机构：

[1] The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, 610 University Avenue, Toronto, M5G 2M9, ON

[2] School of Population and Public Health, University of British Columbia, 2206 East Mall, Vancouver, V6T 1Z9, BC

[3] Prevention and Cancer Control, Cancer Care, 620 University Avenue, Toronto, M5G 2L7, ON

[4] Imaging Research, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, M4N 3M5, ON

[5] Ontario Cancer Institute, 610 University Avenue, Toronto, M5G 2M9, ON

来源：

Breast Cancer Research | / 16卷 / 4期

关键词：

Breast Cancer; Mammographic Density; Stromal Mesenchymal Cell; Interval Cancer; High Tertile;

D O I：

10.1186/s13058-014-0417-7

中图分类号：

学科分类号：

摘要：

Introduction: Percent mammographic density (PMD) is associated with an increased risk of interval breast cancer in screening programs, as are younger age, pre-menopausal status, lower body mass index and hormone therapy. These factors are also associated with variations in PMD. We have examined whether these variables influence the relative frequency of interval and screen-detected breast cancer, independently or through their associations with PMD. We also examined the association of tumor size with PMD and dense and non-dense areas in screen-detected and interval breast cancers. Methods: We used data from three case-control studies nested in screened populations. Interval breast cancer was defined as invasive breast cancer detected within 12 months of a negative mammogram. We used a computer-assisted method of measuring the dense and total areas of breast tissue in the first (baseline) mammogram taken at entry to screening programs and calculated the non-dense area and PMD. We compared these mammographic features, and other risk factors at baseline, in women with screen-detected (n = 718) and interval breast cancer (n = 125). Results: In multi-variable analysis, the baseline characteristics of younger age, greater dense area and smaller non-dense mammographic area were significantly associated with interval breast cancer compared to screen-detected breast cancer. Compared to screen-detected breast cancers, interval cancers had a larger maximum tumor diameter within each mammographic measure. Conclusions: Age and the dense and non-dense areas in the baseline mammogram were independently associated with interval breast cancers in screening programs. These results suggest that decreased detection of cancers caused by the area of dense tissue, and more rapid growth associated with a smaller non-dense area, may both contribute to risk of interval breast cancer. Tailoring screening to individual mammographic characteristics at baseline may reduce the number of interval cancers. © 2014 Boyd et al.

引用

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