Significance of initial emotional state for neuroimmunomodulation in conditions of activation and blockade of 5-HT1A receptors

被引：7

作者：

Idova G.V. ^{[1
]}

Davydova S.M. ^{[1
]}

Cheido M.A. ^{[1
]}

Zhukova E.N. ^{[1
]}

Devoino L.V. ^{[1
]}

机构：

[1] Laboratory for the Mechanisms of Neurochemical Modulation, State Research Institute of Physiology, Russian Academy of Medical Sciences, Novosibirsk

来源：

Neuroscience and Behavioral Physiology | 2006年 / 36卷 / 7期

基金：

俄罗斯基础研究基金会;

关键词：

5-HT1Areceptors; 8-OH-DPAT; Aggression; Emotional state; Immune response; Neuroimmunomodulation; Submission; WAY-100635;

D O I：

10.1007/s11055-006-0076-y

中图分类号：

学科分类号：

摘要：

Experiments performed on male CBA mice immunized with sheep erythrocytes at a dose of 5·108 cells showed that the selective agonist of serotonin 5-HT1A receptors 8-OH-DPAT (1 mg/kg) suppresses the immune response in aggressive animals. In mice demonstrating the submissive type of behavior, formed during 10 days of experience of defeats, activation of 5-HT1A receptors with 8-OH-DPAT had no effect on the immune response. However, treatment with the selective 5-HT1A receptor blocker WAY-100635 stimulated the immune response, but only in submissive mice. These data lead to the conclusion that activation and blockade of 5-HT1A receptors have different effects on the immune response in CBA mice depending on the initial emotional state of the animals, due to different activities of neurotransmitter systems, particularly the serotoninergic, in aggressive and submissive mice. © Springer Science+Business Media, Inc. 2006.

引用

页码：703 / 707

页数：4

共 30 条

[1]

Vishnevetskaya G.B., Plyusnina I.Z., Popova N.K., Involvement of 5-HT1A receptors in the regulation of various types of aggressive behavior, Zh. Vyssh. Nerv. Deyat., 51, 6, pp. 704-708, (2001)

[2]

Gainetdinov R.R., Bogdanov M.B., Kudrin V.S., Raevskii K.S., Selective analyzers of D2 dopamine receptors modulate serotonin metabolism in the striatum and nucleus accumbens of the rat brain in conditions of blockade of dopaminergic spike activity, Byull Éksperim. Biol. Med., 113, 6, pp. 614-619, (1992)

[3]

Gorbunova A.V., Biogenic amines in the brain structures of rats of different zoosocial ranks in immobilization stress, Byull.Éksperim. Biol. Med., 113, 6, pp. 570-572, (1992)

[4]

Devoino L.V., Al'perina E.L., Kudryavtseva N.N., Popova N.K., Changes in the immune response in male mice with aggressive and submissive types of behavior, Fiziol. Zh. SSSR, 77, 12, pp. 62-67, (1991)

[5]

Devoino L.V., Al'perina E.L., Podgornaya E.K., Polyakov O.V., Idova G.V., Il'yuchenok R.Y., Effects of serotonin and 5-hydroxyindoleacetic acid levels in brain structures on the formation of the immune response in aggressive mice of the strain C57Bl/6J, Byull Éksperim. Biol. Med., 130, 10, pp. 399-401, (2000)

[6]

Devoino L.V., Il'yuchenok R.Yu., Neurotransmitter Systems in Psychoneuroimmunomodulation, (1993)

[7]

Idova G.V., Zhukova E.N., Al'perina E.L., Devoino L.V., Effects of the serotonin type 1A receptor agonist 8-OH-DPAT on the immune response, Byull. Éksperim. Biol. Med., 132, 10, pp. 432-434, (2001)

[8]

Idova G.V., Pavina T.A., Al'perina E.L., Devoino L.V., Effects of the submissive and aggressive types of behavior on changes in bone marrow CD4+ and CD8+ T-lymphocyte counts, Immunologiya, 1, pp. 24-26, (2000)

[9]

Idova G.V., Cheido M.A., Zhukova E.N., Devoino L.V., Stimulation of the immune response on activation of the dopaminergic system in mice with opposite types of behavior, Ros. Fiziol. Zh. Im. I. M. Sechenova, 88, 11, pp. 1394-1400, (2002)

[10]

Kryzhanovskii G.N., Magaeva S.V., Makarov S.V., Sepiashvili R.I., Neuroimmunopathology, (2003)

← 1 2 3 →