Depression in the medically ill: Diagnostic and therapeutic implications

被引：8

作者：

Narasimhan M. ^{[1
]}

Raynor J.D. ^{[1
]}

Jones A.B. ^{[1
]}

机构：

[1] Office of Biological Research, Department of Neuropsychiatry and Behavioral Science, University of South Carolina School of Medicine, Columbia, SC 29203

来源：

Current Psychiatry Reports | 2008年 / 10卷 / 3期

关键词：

Depressive Symptom; Major Depressive Disorder; Medical Illness; Biol Psychiatry; General Medical Condition;

D O I：

10.1007/s11920-008-0044-z

中图分类号：

学科分类号：

摘要：

Depression and medical comorbidities lead to increased morbidity and mortality and have been associated with higher health care costs. Depressive disorders can adversely impact the course of medical illnesses, whereas medical illnesses can serve as a risk factor for future depressive disorders. This interplay has spurred some interesting exploratory research to understand the common pathophysiology and neurobiologic substrates that may explain the bidirectional relationship between the two disorders. There is a paucity of well-designed, randomized, controlled trials to address some of the treatment-related progrostic issues in this population. However, more recent studies have focused on diagnostic and treatment implications with various available pharmacologic and psychotherapeutic modalities. Early identification and appropriate treatment of depression in the medically ill can positively influence medical outcomes and quality of life. Collaborative care models integrating mental health and primary care providers, combined with patient preference, are found to be cost-effective and may result in better response to depression treatment. Copyright © 2008 by Current Medicine Group LLC.

引用

页码：272 / 279

页数：7

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