Ceasing of muscle function with aging: Is it the consequence of intrinsic muscle degeneration or a secondary effect of neuronal impairments?

被引：8

作者：

Figueiredo P.A. ^{[1
]}

Mota M.P. ^{[2
]}

Appell H.J. ^{[1
,3
]}

Duarte J. ^{[1
]}

机构：

[1] Faculty of Sports, Centro de Investigação Em Actividade Fìsica, Saúde e Lazer, 4200-450 Porto, R. Dr. Plácido Costa

[2] University of Trás-os-Montes and Alto Douro, Vila Real

[3] Department of Physiology and Anatomy, German Sport University, Cologne

来源：

European Review of Aging and Physical Activity | 2006年 / 3卷 / 2期

关键词：

Functional impairment; Neuropathy; Sarcopenia; Skeletal muscle aging;

D O I：

10.1007/s11556-006-0011-9

中图分类号：

学科分类号：

摘要：

Aging is associated with a significant decline in neuromuscular function leading to an eventual loss of independence and mobility of senescent people. Age-related sarcopenia, characterised by a reduction in muscle mass and strength, is considered one of the most striking features of aging at the level of the skeletal muscle. Morphological alterations in skeletal muscle can be considered as one of the consequences responsible for muscle weakness in the aged population. Beyond 60 years of age, human muscle undergoes a process of continuous denervation and reinnervation, due to an accelerating loss of motor units. It appears evident that phenotypic alterations in muscle depend on the motor drives provided by the nervous system. Because the peripheral nerves, the neuromuscular junction and motor neurons exhibit degenerative features during advanced age, sarcopenia does not seem to intrinsically develop, but is rather a secondary effect of impaired neuronal function. It is therefore recommended that elderly subjects undergo an exercise program that is aimed towards the improvement of coordinative skills and of muscle strength. © EGREPA 2006.

引用

页码：75 / 83

页数：8

共 67 条

[1]

Adhihetty P., Hood D., Mechanisms of apoptosis in skeletal muscle, Basic Appl Myol, 13, 4, pp. 171-179, (2003)

[2]

Akataki K., Mita K., Watakabe M., Ito K., Age-related change in motor unit activation strategy in force production: A mechanomyographic investigation, Muscle Nerve, 25, 4, pp. 505-512, (2002)

[3]

Andersen J.L., Muscle fibre type adaptation in the elderly human muscle, Scand J Med Sci Sports, 13, 1, pp. 40-47, (2003)

[4]

Andonian M.H., Fahim M.A., Effects of endurance exercise on the morphology of mouse neuromuscular junctions during ageing, J Neurocytol, 16, 5, pp. 589-599, (1987)

[5]

Ansved T., Edstrom L., Effects of age on fibre structure, ultrastructure and expression of desmin and spectrin in fast- And slow-twitch rat muscles, J Anat, 174, pp. 61-79, (1991)

[6]

Balice-Gordon R.J., Lichtman J.W., In vivo observations of pre- And postsynaptic changes during the transition from multiple to single innervation at developing neuromuscular junctions, J Neurosci, 13, 2, pp. 834-855, (1993)

[7]

Balice-Gordon R.J., Age-related changes in neuromuscular innervation, Muscle Nerve, 5 SUPPL., (1997)

[8]

Booth F.W., Weeden S.H., Tseng B.S., Effect of aging on human skeletal muscle and motor function, Med Sci Sports Exerc, 26, 5, pp. 556-560, (1994)

[9]

Brooks S.V., Faulkner J.A., Skeletal muscle weakness in old age: Underlying mechanisms, Med Sci Sports Exerc, 26, 4, pp. 432-439, (1994)

[10]

Bua E.A., McKiernan S.H., Wanagat J., McKenzie D., Aiken J.M., Mitochondrial abnormalities are more frequent in muscles undergoing sarcopenia, J Appl Physiol, 92, 6, pp. 2617-2624, (2002)

← 1 2 3 4 5 6 7 →