Update on childhood-onset schizophrenia.

被引：32

作者：

Rapoport J.L. ^{[1
]}

Inoff-Germain G. ^{[1
]}

机构：

[1] Room, National Institute of Mental Health, 10 Center Drive, Child Psychiatry Branch (Building 10, Bethesda, 20892-1600, MD

来源：

Current Psychiatry Reports | 2000年 / 2卷 / 5期

关键词：

Schizophrenia; Aripiprazole; Acad Child Adolesc Psychiatry; Magnetic Resonance Spectroscopic Imaging; Onset Schizophrenia;

D O I：

10.1007/s11920-000-0024-4

中图分类号：

学科分类号：

摘要：

Updated findings from the ongoing National Institute of Mental Health Child Psychiatry Branch longitudinal study of childhood-onset schizophrenia (COS) are presented, along with replications from collaborators at other sites. Clinical and neurobiologic continuities of COS with poor-outcome adult-onset schizophrenia suggests that their underlying pathophysiology is the same. However, these early-onset cases appear to have more striking genetic contributions to their etiology. Updated findings involve risk factors (birth complications, cytogenic abnormalities, early language and motor problems, and familial psychopathology), treatment trials, and brain magnetic resonance imaging studies.

引用

页码：410 / 415

页数：5

共 134 条

[1]

Childs B(1986)Age at onset and causes of disease Perspect Biol Med 29 437-460

[2]

Scriver CR(1994)Childhood-onset schizophrenia: an NIMH study in progress Schizophr Bull 20 697-712

[3]

Gordon CT(1998)Research update: childhood-onset schizophrenia: implications of clinical and neurobiological research J Child Psychol Psychiatry 39 101-113

[4]

Frazier JA(1999)Childhood-onset schizophrenia: rare but worth studying Biol Psychiatry 46 1418-1428

[5]

McKenna K(1971)Studies in the childhood psychoses: I. Diagnostic criteria and classification Br J Psychiatry 118 381-384

[6]

Jacobsen LK(1971)Studies in childhood psychoses: II. The phenomenology of childhood psychoses Br J Psychiatry 118 385-395

[7]

Rapoport JL(1994)Looking for childhood-onset schizophrenria: the first 71 cases screened J Am Acad Child Adolesc Psychiatry 33 636-644

[8]

Nicolson R(1995)Childhoodonset schizophrenia: the severity of premorbid course J Am Acad Child Adolesc Psychiatry 34 1273-1283

[9]

Rapoport JL(2000)Premorbid speech and language impairments in childhood onset schizophrenia: association with risk factors Am J Psychiatry 157 794-800

[10]

Kolvin I(1994)Cognitive/neuropsychological studies of children with a schizophrenic disorder Schizophr Bull 20 647-669

← 1 2 3 4 5 6 7 8 9 10 →