Pediatric multiple sclerosis

被引：36

作者：

Banwell B.L. ^{[1
]}

机构：

[1] Department of Pediatrics Neurology, The Hospital for Sick Children, Toronto, Ont. M5G 1X8

来源：

Current Neurology and Neuroscience Reports | 2004年 / 4卷 / 3期

关键词：

Multiple Sclerosis; West Nile Virus; Optic Neuritis; Glatiramer Acetate; Acute Disseminate Encephalomyelitis;

D O I：

10.1007/s11910-004-0045-1

中图分类号：

学科分类号：

摘要：

The onset of multiple sclerosis (MS) in childhood is being increasingly recognized. Despite this, there currently exist several barriers to the prompt diagnosis of MS in children, Many clinicians view MS as an exclusively adult-onset disease, and thus they may not entertain the diagnosis in a child. Also, the clinical and radiographic criteria for the diagnosis of MS have not been validated in a pediatric MS population. The available literature, as well as experience gained in a dedicated pediatric MS clinic, is used here to describe features of pediatric MS and contrast these with adult MS. The rationale and importance of future studies in pediatric MS is highlighted. Copyright © 2004 by Current Science Inc.

引用

页码：245 / 252

页数：7

共 69 条

[1] Noseworthy J., Lucchinetti C., Rodriguez M., Weinshenker B., Multiple sclerosis, N. Engl. J. Med., 343, pp. 938-952, (2000)
[2] Duquette P., Murray T.J., Pleines J., Et al., Multiple sclerosis in childhood: Clinical profile in 125 patients, J. Pediatr., 111, pp. 359-363, (1987)
[3] Houzen H., Niino M., Kikuchi S., Et al., The prevalence and clinical characteristics of MS in northern Japan, J. Neurol. Sci., 211, pp. 49-53, (2003)
[4] Itoh T., Aizawa H., Hashimoto K., Et al., Prevalence of multiple sclerosis in Asahikawa, a city in northern Japan, J. Neurol. Sci., 214, pp. 7-9, (2003)
[5] Pugliatti M., Sotgiu S., Rosati G., The worldwide prevalence of multiple sclerosis, Clin. Neurol. Neurosurg., 104, pp. 182-191, (2002)
[6] Sadovnick A.D., Ebers G.C., Epidemiology of multiple sclerosis: A critical overview, Can. J. Neurol. Sci., 20, pp. 17-29, (1993)
[7] Barcellos L.F., Oksenberg J.R., Begovich A.B., Et al., HLA-DR2 dose effect on susceptibility to multiple sclerosis and influence on disease course, Am. J. Hum. Genet., 72, pp. 710-716, (2003)
[8] Ligers A., Dyment D.A., Willer C.J., Et al., Evidence of linkage with HLA-DR in DRB1 * 15-negative families with multiple sclerosis, Am. J. Hum. Genet., 69, pp. 900-903, (2001)
[9] Dyment D.A., Sadovnick A.D., Ebers G.C., Sadnovich A.D., Genetics of multiple sclerosis, Hum. Mol. Genet., 6, pp. 1693-1698, (1997)
[10] Hauser S.L., Fleischnick E., Weiner H.L., Et al., Extended major histocompatibility complex haplotypes in patients with multiple sclerosis, Neurology, 39, pp. 275-277, (1989)

← 1 2 3 4 5 6 7 →