New prognostic factors associated with long-term survival in node-negative breast cancer patients

被引：10

作者：

Kato T. ^{[1
]}

Kimura T. ^{[1
]}

Takami N. ^{[1
]}

Miyakawa R. ^{[1
]}

Tanaka S. ^{[1
]}

Muraici H. ^{[1
]}

Kamio T. ^{[1
]}

Fujii A. ^{[1
]}

Yamamoto K. ^{[1
]}

Kameoka S. ^{[1
]}

Nishikawa T. ^{[2
]}

Kasajima T. ^{[3
]}

机构：

[1] Department of Surgery II, School of Medicine, Tokyo Women's Medical University, Shinjuku-ku, Tokyo 162-8666

[2] Department of Surgical Pathology, School of Medicine, Tokyo Women's Medical University

[3] Department of Pathology, School of Medicine, Tokyo Women's Medical University

来源：

Breast Cancer | 1999年 / 6卷 / 4期

关键词：

Angiogenesis; Clinical tumor size; Long-term survival; Node-negative breast cancer; Proliferating cell nuclear antigen (PCNA);

D O I：

10.1007/BF02966456

中图分类号：

学科分类号：

摘要：

Background: This study was undertaken to determine the absolute and relative value of angiogenesis, proliferating cell nuclear antigen (PCNA) and conventional prognostic factors in predicting relapse-free survival (RFS) and overall survival (OS) rates associated with long-term survival in Japanese patients with node-negative breast cancer. Patients and Methods: Two hundred patients with histological node-negative breast cancer were studied. We investigated nine clinicopathological factors, including angiogenesis, PCNA using permanent-section immunohistochemistry, clinical tumor size, histological grade (HG), tumor necrosis, lymphatic vessel invasion (LVI), histological extension, histological classification, and infiltrating growth (INF), followed for a median of 10 years (range, 1 to 20). Results: Twenty-one patients (10.5%) had recurrence and 15 patients [7.5%) died of breast cancer. Univariate analysis showed that PCNA, clinical tumor size, HG, angiogenesis, and LVI were significantly predictive of 20-year RFS or OS. Tumor necrosis was significantly predictive of OS, not of RFS. Multivariate analysis showed that clinical tumor size (P = 0.0003), angiogenesis (P = 0.0003), PCNA [P = 0.0064), and HG (P = 0.0401) were significant independent prognostic factors for RFS. PCNA [P< 0.0001) and clinical tumor size (P = 0.0112) were significant independent prognostic factors for OS, while angiogenesis was a borderline significant factor. Conclusion: PCNA and angiogenesis were important new prognostic factors in node-negative breast cancer patients.

引用

页码：370 / 377

页数：7

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