Dengue Virus Infection among Children with Undifferentiated Fever in Karachi

被引：51

作者：

Akram D.S. ^{[1
]}

Igarashi A. ^{[2
]}

Takasu T. ^{[2
]}

机构：

[1] Department of Paediatrics, Dow Medical College, Civil Hospital, Karachi

[2] Department of Virology, Institute for Tropical Medicine, Nagasaki University

来源：

The Indian Journal of Pediatrics | 1998年 / 65卷 / 5期

关键词：

Dengue virus; Undifferentiated fever;

D O I：

10.1007/BF02731055

中图分类号：

学科分类号：

摘要：

Sera were collected from a total of 122 children, comprising 117 cases with undifferentiated fever and 5 cases with dengue hemorrhagic fever (DHF), during June to September 994 in Karachi, Pakistan. Sera were tested by the IgM-capture ELISA using dengue type 1 (D1), dengue type 2 (D2), West Nile (WN), and Japanese encephalitis (JE) viral antigens. Among 92 single sera from undifferentiated fever cases, IgM antibodies were detected in 5 cases by D1, 8 cases by D2, and 5 cases by WN antigens, respectively. Corresponding number of positives among 25 paired sera from undifferentiated fever cases were 3 by D1, 6 by D2, and 1 by WN antigen. Four out of 5 DHF cases possessed arti-D1 as well as anti-D2 IgM antibodies. Only a single DHF case was positive for anti-WN IgM antibodies. Anti-JE IgM antibodies were not detected in any of the tested serum specimens. Clinical manifestations of undifferentiated fever patients were generally non specific, but the percentage of children with anemia, hepatomegaly and splenomegaly was higher in patients possessing anti-dengue IgM antibodies than those without. Among the groups with anti-dengue IgM antibodies, those possessing only anti-D2 but not anti-D1 IgM antibodies showed higher percentages with cough, edema, and splenomegaly. The results indicated that up to 26% of the undifferentiated fever cases were caused by dengue virus infection in Karachi, Pakistan.

引用

页码：735 / 740

页数：5

共 15 条

[1]

Mosquito-borne hemorrhagic fevers of Southeast Asia and Western Pacific (1966) Bull WHO, 35, pp. 17-33

[2]

Halstead, S.B., Dengue haemorrhagic fever - A public health problem and a field for research (1980) Bull WHO, 58, pp. 1-21

[3]

Halstead, S.B., The XXth century dengue pandemic : Need for surveillance and research (1992) Wld Hlth Statist Quart, 45, pp. 292-298

[4]

Westaway, E.G., Brinton, M.A., Gaidamovich, Flaviviridae (1985) Intervirology, 24, pp. 183-192

[5]

Wengler, G., Family - Flaviviridae Arch Virol, (2 SUPPL.), pp. 223-233. , R.I. B. Francki, In R.I. B. Francki, C.M. Fauquet, D.L. Knudson, F. Brown (eds.). Classification and Nomenclature of Viruses : Springer-Verlag, Wien, New York

[6]

Rice, C.M., Lenches, E.M., Eddy, S.R., Shin, S.J., Sheets, R.L., Strauss, J.H., Nucleotide sequence of yellow fever virus : Implications for flavivirus gene expression and evolution (1985) Science, 299, pp. 726-733

[7]

Rudnick, A., Marchettes, N.J., Garcia, R., Possible jungle dengue - Recent studies and hypothesis (1967) Jpn J Med Sci Biol, 20, pp. 69-74

[8]

Sumarmo Wulur, H., Jahja, E., Gubler, D.J., Sutomenggolo, T.S., Sulianti Saroso, J., Encephalopathy associated with dengue infection (1978) Lancet, 1, pp. 449-450

[9]

Banerjee, K., Dengue fever in rural areas of Maharashtra and Gujarat States in India (1990) Dengue News, 15, pp. 3-5

[10]

Mehardale, S.M., Risbud, A.R., Outbreak of dengue fever in rural areas of Parbhani district of Maharashtra (India) (1991) Ina J Med Res (A), 93, pp. 6-11

← 1 2 →