Non-protein amino acids in peptide design

被引：65

作者：

S. Aravinda

N. Shamala

Rituparna S. Roy

P Balaram

机构：

[1] Indian Institute of Science,Department of Physics

[2] Indian Institute of Science,Molecular Biophysics Unit

[3] Jawaharlal Nehru Centre for Advanced Scientific Research,Chemical Biology Unit

来源：

Journal of Chemical Sciences | 2003年 / 115卷 / 5-6期

关键词：

Peptide design; crystal structures; C-H…O hydrogen bond; hybrid peptides; D-amino acids; -amino acids;

D O I：

10.1007/BF02708230

中图分类号：

学科分类号：

摘要：

An overview of the use of non-protein amino acids in the design of conformationally well-defined peptides, based on work from the author’s laboratory, is discussed. The crystal structures of several designed oligopeptides illustrate the useα-aminoisobutyric acid (Aib) in the construction of helices, D-amino acids in the design of helix termination segments andDPro-Xxx segments for nucleating ofβ-hairpin structures.β- andγ-amino acid residues have been used to expand the range of designed polypeptide structures.

引用

页码：373 / 400

页数：27

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