High end GPCR design: crafted ligand design and druggability analysis using protein structure, lipophilic hotspots and explicit water networks

被引:60
作者
Jonathan S Mason
Andrea Bortolato
Dahlia R Weiss
Francesca Deflorian
Benjamin Tehan
Fiona H Marshall
机构
[1] Heptares Therapeutics Ltd,CADD/Computational Chemistry
[2] CSO,undefined
[3] Heptares Therapeutics Ltd,undefined
关键词
GPCR; StaR; GRID; WaterMap; WaterFLAP; metadynamics; A;
D O I
10.1186/2193-9616-1-23
中图分类号
学科分类号
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