Transport and Metabolism of the Tea Flavonoid (–)-Epicatechin by the Human Intestinal Cell Line Caco-2

被引：32

作者：

Jaya Bharathi Vaidyanathan

Thomas Walle

机构：

[1] Medical University of South Carolina,Department of Cell and Molecular Pharmacology and Experimental Therapeutics

来源：

Pharmaceutical Research | 2001年 / 18卷

关键词：

tea flavonoids; epicatechin; transport; metabolism; Caco-2 cells;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Purpose: Tea flavonoids, including (–)-epicatechin (EC), have been suggested to have chemopreventive properties in cancer. However, there is limited knowledge of the oral bioavailability of these dietary compounds. The purpose of this study was to gain a better understanding of the absorption of EC.

引用

页码：1420 / 1425

页数：5

共 113 条

[1]

Hertog M. G. L.(1992)Content of potentially anticarcinogenic flavonoids of 28 vegetables and 9 fruits commonly consumed in the Netherlands J. Agric. Food Chem. 40 2379-2383

[2]

Hollman P. C. H.(1993)Content of potentially anticarcinogenic flavonoids of tea infusions, wines and fruit juices J. Agric. Food Chem. 41 1242-1246

[3]

Katan M. B.(2000)Catechin contents of foods commonly consumed in the Netherlands. 2. Tea, wine, fruit juices, and chocolate milk J. Agric. Food Chem. 48 1752-7

[4]

Hertog M. G. L.(1993)Tea and cancer J. Natl. Cancer Inst. 85 1038-49

[5]

Hollman P. C. H.(1998)Effect of phytochemicals on CYP 450 linked alkoxyresorufin O-dealkylase activity Phyto. Res. 12 89-93

[6]

van de Putte B.(1996)Tea in chemoprevention of cancer Int. J. Oncol. 7 133-141

[7]

Arts I. C.(1997)(−)-Epigallocatechin-3-gallate blocks the induction of nitric oxide synthase by down-regulating lipopolysaccharide-induced activity of transcription factor nuclear factor-kappaB Mol. Pharmacol. 52 465-472

[8]

van De Putte B.(1997)Inhibition of tumor promoter-induced activator protein 1 activation and cell transformation by tea polyphenols, (−)-epigallocatechin gallate, and theaflavins Cancer Res. 57 4414-4419

[9]

Hollman P. C.(1995)Analysis of plasma and urinary tea polyphenols in human subjects Cancer Epidemiol. Biomarkers Prev. 4 393-399

[10]

Yang C. S.(1998)Blood and urine level of tea catechin after ingestion of different amounts of green tea by human volunteers Cancer Epidemiol. Biomarkers Prev. 7 351-354

← 1 2 3 4 5 6 7 8 9 10 →