Long term effects of micro-surgical testicular sperm extraction on androgen status in patients with non obstructive azoospermia

被引：38

作者：

Everaert K. ^{[1
]}

De Croo I. ^{[2
]}

Kerckhaert W. ^{[1
]}

Dekuyper P. ^{[1
]}

Dhont M. ^{[2
]}

Van Der Elst J. ^{[2
]}

De Sutter P. ^{[2
]}

Comhaire F. ^{[2
]}

Mahmoud A. ^{[3
]}

Lumen N. ^{[1
]}

机构：

[1] Department of Urology, Ghent University Hospital, B-9000 Ghent

[2] Department of Gynaecology, Ghent University Hospital, B-9000 Ghent

[3] Department of Endocrinology, Ghent University Hospital, B-9000 Ghent

来源：

BMC Urology | / 6卷 / 1期

关键词：

Seminiferous Tubule; Varicocele; Serum Testosterone; Azoospermia; Serum Testosterone Level;

D O I：

10.1186/1471-2490-6-9

中图分类号：

学科分类号：

摘要：

Background: The aim of our study was to review the results of microsurgically performed testicular sperm extraction (TESE) and to evaluate its possible long term effects on serum testosterone (T). Methods: We operated on 48 men (35 +/- 8 years) with non-obstructive azoospermia (NOA). If no spermatozoa were found following a micro epididymal sperm extraction (Silber et al., 1994) and testicular biopsy, testicular microdissection was performed or multiple microsurgical testicular biopsies were taken. The mean follow-up of the serum T was 2.4 +/- 1.1 years. Results: Sperm was retrieved in 17/48 (35%) of the men. The per couple take home baby rate if sperm was retrieved was 4/17 (24%). Serum T decreased significantly at follow-up (p < 0.05) and 5/31 (16%) de novo androgen deficiencies developed Conclusion: In patients with non-obstructive azoospermia in whom no spermatozoa were found following a micro epididymal sperm aspiration and a simple testicular biopsy, we were able to retrieve spermatozoa in 35% of the men. The take home baby rate was 24% among couples with spermatozoa present upon TESE. De novo androgen deficiency occurred in 16% of the male patients following TESE indicating that, in men with NOA, long term hormonal follow up is recommended after TESE. © 2006Everaert et al; licensee BioMed Central Ltd.

引用

共 25 条

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