Association between high-risk HPV types, HLA DRB1* and DQB1* alleles and cervical cancer in British women

被引：105

作者：

Cuzick J. ^{[1
]}

Terry G. ^{[1
]}

Ho L. ^{[1
]}

Monaghan J.

Lopes A.

Clarkson P.

Duncan I. ^{[2
]}

机构：

[1] Dept. of Math., Stat./Epidemiology, Imperial Cancer Research Fund, London WC2A 3PX

[2] Ninewells Hospital, Dundee

来源：

British Journal of Cancer | 2000年 / 82卷 / 7期

关键词：

Cervical cancer; HLA; HPV;

D O I：

10.1054/bjoc.1999.1103

中图分类号：

学科分类号：

摘要：

Cervical scrapes from 116 British women referred with cervical cancer were tested for the presence of high oncogenic risk human papillomavirus (HPV) genotypes (HPV(hr)). Ninety-four per cent of the scrapes had one or more of these virus types and 66% were HPV16-positive. HPV18 was more frequent in adenocarcinoma. No evidence was found for an increased cancer risk associated with the HPV16 E6 350G variant. The HLA DRB1* and DQB1* alleles in these women and in 155 women with normal cytology and negative for HPV(hr) DNA were compared. DQB1*0301 alone (2P = 0.02) and in combination with DRB1*0401 (2P = 0.02) was found to be associated with cervical cancer. This was more marked in cancers positive for HPV types other than HPV16. In contrast, DRB1*1501 alone and in combination with DQB1*0602 was not significantly elevated in cancers overall, but did show some excess in HPV16-positive cancers (2P = 0.05), associated with HPV16-positive cervical cancers. Taking all cancers together, a marginally significant protective effect was found for DQB1*0501 (2P = 0.03) but no protective effect could be seen for DRB1*1301. (C) 2000 Cancer Research Campaign.

引用

页码：1348 / 1352

页数：4

共 21 条

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