Inter-population variations in concentrations, determinants of and correlations between 2,2′,4,4′,5,5′-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene (p,p′-DDE): A cross-sectional study of 3161 men and women from Inuit and European populations

被引：77

作者：

Jönsson B.A.G. ^{[1
]}

Rylander L. ^{[1
]}

Lindh C. ^{[1
]}

Rignell-Hydbom A. ^{[1
]}

Giwercman A. ^{[2
]}

Toft G. ^{[3
]}

Pedersen H.S. ^{[4
]}

Ludwicki J.K. ^{[5
]}

Góralczyk K. ^{[5
]}

Zvyezday V. ^{[6
]}

Spanò M. ^{[7
]}

Bizzaro D. ^{[8
]}

Bonefeld-Jörgensen E.C. ^{[9
]}

Manicardi G.C. ^{[10
]}

Bonde J.P. ^{[3
]}

Hagmar L. ^{[1
]}

机构：

[1] Department of Occupational and Environmental Medicine, Lund University Hospital

[2] Scanian Fertility Centre, Malmö University Hospital, Malmö

[3] Department of Occupational Medicine, Aarhus University Hospital, Build. 2C, DK-8000 Aarhus C

[4] Centre for Arctic Environmental Medicine, DK-3900 Nuuk, Greenland

[5] Department of Environmental Toxicology, National Institute of Hygiene, Warsaw, P-00-791 Warsaw

[6] Laboratory of Human Reproduction, Kharkiv State Medical University, 61145 Kharkiv

[7] Section of Toxicology and Biomedical Sciences, BIOTEC-MED, ENEA CR Casaccia, 00060 Rome

[8] Istituto di Biologia e Genetica, Università Politecnica Delle Marche, I-60131 Ancona, Via Brecce Bianche

[9] Institute of Public Health, Department of Environmental and Occupational Medicine, University of Aarhus, DK-8000 Aarhus C

[10] Laboratorio di Genetica, Dip. di Science Agrarie, Università di Modena e Reggio Emilia, Reggio Emilia I-41100 Modena

来源：

Environmental Health | / 4卷 / 1期

关键词：

High Serum Concentration; Gestational Length; Exposure Source; Inuit Woman; Persistent Organochlorine Pollutant;

D O I：

10.1186/1476-069X-4-27

中图分类号：

学科分类号：

摘要：

Background: The study is part of a collaborative project (Inuendo), aiming to assess the impact of dietary persistent organochlorine pollutants (POPs) on human fertility. The aims with the present study are to analyze inter-population variations in serum concentrations of 2,2′,4,4′,5,5′- hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene (p,p′-DDE), to assess inter-population variations in biomarker correlations, and to evaluate the relative impact of different determinants for the inter-individual variations in POP-biomarkers. Method: In study populations of 3161 adults, comprising Greenlandic Inuits, Swedish fishermen and their wives, and inhabitants from Warsaw, Poland and Kharkiv, Ukraine, serum concentrations of CB-153 and p,p′-DDE, were analysed by gas chromatography-mass spectrometry. Results: The median serum concentrations of CB-153 were for male and female Inuits 200 and 110, for Swedish fishermen 190 and their wives 84, for Kharkiv men and women 44 and 27, and for Warsaw men and women 17 and 11 ng/g lipids, respectively. The median serum concentrations of p,p′-DDE were for Kharkiv men and women 930 and 650, for male and female Inuits 560 and 300, for Warsaw men and women 530 and 380, and for Swedish fishermen 240 and their wives 140 ng/g lipids, respectively. The correlation coefficients between CB-153 and p,p′-DDE varied between 0.19 and 0.92, with the highest correlation among Inuits and the lowest among men from Warsaw. Men had averagely higher serum concentrations of CB-153 and p,p′-DDE, and there were positive associations between age and the POP-biomarkers, whereas the associations with BMI and smoking were inconsistent. Dietary seafood was of importance only in the Inuit and Swedish populations. Conclusion: CB-153 concentrations were much higher in Inuits and Swedish fishermen's populations than in the populations from Eastern Europe, whereas the pattern was different for p,p′-DDE showing highest concentrations in the Kharkiv population. The correlations between the POP-biomarkers varied considerably between the populations, underlining that exposure sources differ and that the choice of representative biomarkers of overall POP exposure has to be based on an analysis of the specific exposure situation for each population. Age and gender were consistent determinants of serum POPs; seafood was of importance only in the Inuit and Swedish populations. © 2005 Jönsson et al; licensee BioMed Central Ltd.

引用

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