Endocrine and metabolic changes in human aging

被引：6

作者：

Banks W.A. ^{[1
,2
,3
]}

Morley J.E. ^{[1
,2
]}

机构：

[1] Division of Geriatric Medicine, Saint Louis University Medical School, 915 N. Grand Blvd., St. Louis

[2] Geriatric Research, Education and Clinical Center, St. Louis VAMC, St. Louis

[3] Veterans Affairs Medical Center-St. Louis Division of Geriatrics, Department of Internal Medicine, Saint Louis University Medical School, 915 N. Grand Blvd., St. Louis

来源：

Journal of the American Aging Association | 2000年 / 23卷 / 2期

关键词：

Receptor Gene; Regulatory System; Insulin Receptor; Aging Process; Metabolic Change;

D O I：

10.1007/s11357-000-0011-z

中图分类号：

学科分类号：

摘要：

Numerous alterations in hormonal secretion occur with aging. In general, these tend towards a disintegration of the normal cyclic secretory patterns resulting in lower total circulating levels. In addition, declines in receptors and postreceptor function further decreases the ability of the hormonal orchestra to maintain coordinated function throughout the organism. Clues to some of these age-related changes in humans may come from the study of simpler organisms where regulatory systems are known to modulate the aging process. In particular, the interactions among the environment, hormones, and insulin receptor genes have led to new insights into the genetic control of longevity and the development of syndrome X.

引用

页码：103 / 115

页数：12

共 126 条

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