Role of cytokines in postmenopausal bone loss.

被引：34

作者：

Johannes Pfeilschifter

机构：

[1] Berufsgenossenschaftliche Kliniken Bergmannsheil, Department of Medicine, University of Bochum, Bürkle-de-la-Camp-Platz 1, Bochum

来源：

Current Osteoporosis Reports | 2003年 / 1卷 / 2期

关键词：

Estrogen; Bone Loss; Estrogen Deficiency; Cytokine Activity; Estrogen Response Element;

D O I：

10.1007/s11914-003-0009-4

中图分类号：

学科分类号：

摘要：

It is increasingly recognized that changes in cytokine activity are involved in the pathophysiology of postmenopausal bone loss in many ways. Estrogen may affect skeletal cytokine activity by diverse mechanisms such as direct interference with cytokine gene transcription, regulation of major signaling molecules, changes in lymphocyte function, and central effects on the hypothalamic-pituitary-adrenal axis. This article summarizes our current knowledge of these interactions and discusses the possible implications with respect to the prevention and treatment of postmenopausal osteoporosis.

引用

页码：53 / 58

页数：5

共 108 条

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