Understanding spermatogenesis is a prerequisite for treatment

被引:159
作者
Adolf-Friedrich Holstein
Wolfgang Schulze
Michail Davidoff
机构
[1] Univ. Hospital Hamburg-Eppendorf, 20246 Hamburg
关键词
Germ Cell; Sertoli Cell; Leydig Cell; Seminiferous Tubule; Primary Spermatocyte;
D O I
10.1186/1477-7827-1-107
中图分类号
学科分类号
摘要
Throughout spermatogenesis multiplication, maturation and differentiation of germ cells results in the formation of the male gamete. The understanding of spermatogenesis needs detailed informations about the organization of the germinal epithelium, the structure and function of different types of germ cells, endocrine and paracrine cells and mechanisms, intratesticular and extratesticular regulation of spermatogenesis. Normal germ cells must be discriminated from malformed, apoptotic and degenerating germ cells and tumor cells. Identification of the border line between normal and disturbed spermatogenesis substantiate the diagnosis of impaired male fertility. The profound knowledge of the complicate process of spermatogenesis and all cells or cell systems involved with is the prerequisite to develop concepts for therapy of male infertility or to handle germ cells in the management of assisted reproduction. © 2003 Holstein et al; licensee BioMed Central Ltd.
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页数:16
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共 34 条
[1]  
Holstein A.F., Spermatogenese beim Menschen: Grundlagenforschung und Klinik, Ann. Anat., 181, pp. 427-436, (1999)
[2]  
Middendorff R., Muller D., Mewe M., Mukhopadhyay A.K., Holstein A.F., Davidoff M.S., The tunica albuginea of the human testis is characterized by complex contraction and relaxation activities regulated by cyclic GMP, J. Clin. Endocrinol. Metabol., 87, pp. 3486-3499, (2002)
[3]  
Roosen-Runge E.C., Holstein A.F., The human rete testis, Cell Tissue Res., 189, pp. 409-433, (1978)
[4]  
Davidoff M.S., Breucker H., Holstein A.F., Seidel K., Cellular architecture of the lamina propria of human seminiferous tubules, Cell Tissue Res., 262, pp. 253-261, (1990)
[5]  
Russell L.D., Griswold M.D., The Sertoli Cell, (1993)
[6]  
Holstein A.F., Maekawa M., Nagano T., Davidoff M.S., Myofibroblasts in the lamina propria of human seminiferous tubules are dynamic structures of heterogeneous phenotype, Arch. Histol. Cytol., 59, pp. 109-125, (1996)
[7]  
Roosen-Runge E.C., The process of spermatogenesis in animals, (1977)
[8]  
Clermont Y., Renewal of spermatogonia in man, Amer. J. Anat., 118, pp. 509-529, (1966)
[9]  
Holstein A.F., Roosen-Runge E.C., Schirren C., Illustrated pathology of human spermatogenesis, (1988)
[10]  
Holstein A.F., Bustos-Obregon E., Hartmann M., Dislocated type-A spermatogonia in human seminiferous tubules, Cell Tissue Res., 236, pp. 35-40, (1984)