Modeling survival in colon cancer: A methodological review

被引：44

作者：

Ahmed F.E. ^{[1
]}

Vos P.W. ^{[2
]}

Holbert D. ^{[2
]}

机构：

[1] Department of Radiation Oncology, The Brody School of Medicine, East Carolina University, Greenville, NC 27858

[2] Department of Biostatistics, School of Allied Health Sciences, East Carolina University, Greenville

来源：

Molecular Cancer | / 6卷 / 1期

关键词：

Hazard Function; Survival Function; Baseline Hazard Function; Additive Hazard Model; Nonproportional Hazard;

D O I：

10.1186/1476-4598-6-15

中图分类号：

学科分类号：

摘要：

The Cox proportional hazards model is the most widely used model for survival analysis because of its simplicity. The fundamental assumption in this model is the proportionality of the hazard function. When this condition is not met, other modifications or other models must be used for analysis of survival data. We illustrate in this review several methodological approaches to deal with the violation of the proportionality assumption, using survival in colon cancer as an illustrative example. © 2007 Ahmed et al; licensee BioMed Central Ltd.

引用

共 32 条

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