Six-monthly de-worming in infants to study effects on growth

被引：29

作者：

Awasthi S. ^{[1
,2
]}

Pande V.K. ^{[1
]}

机构：

[1] Department of Pediatrics, Clinical Epidemiology Unit, King George's Medical College, Lucknow

[2] C-29 Sector C, Aliganj

来源：

The Indian Journal of Pediatrics | 2001年 / 68卷 / 9期

关键词：

Albendazole; De-worming; Growth; Infant; Underweight;

D O I：

10.1007/BF02762101

中图分类号：

学科分类号：

摘要：

Objective: The study was conducted to assess the effectiveness of six monthly albendazole (ABZ) for improving the weight and height of preschool children when initia ted at 0.5-1 year of age in populations with a high transmission rate of intestinal roundworm, Ascaris lumbricoides. It was a cluster randomized trial in the urban slums of Lucknow, North India. Methods: Control children received 2 ml (1 ml to infants) of Vitamin A every six month whereas those in the ABZ areas received, in addition, 400 mg of ABZ suspension (Zentel, SKB) every six month. Sixty-three and sixty-one slum areas were randomized to albendazole (ABZ) or to control groups, respectively. Children aged 0.5-1 year were recruited in April 1996 and followed up for 1.5 years. Of 1022 children recruited from control and 988 from ABZ areas, the loss to follow-up at 1.5 year was 15.6% and 14.6% respectively. Mean (± SE) weight gain in Kg in control versus ABZ areas was 3.04 (0.03) versus 3.22 (0.03), (p=0.01). Results: After controlling for the presence of weight-for age z-score <-2.00 at enrollment in the ordinary least square's regression model, the extra weight gain in 1.5 years in those who received ABZ plus vitamin A was 0.13 Kg (95% Cl:0.004 to 0.26 Kg., p value=0.043) when compared to those who received only vitamin A; underweight children at enrollment benefiting more than the normal ones. Conclusion: It was concluded that there was an improvement in weight with six monthly ABZ over 1.5 years. However, a much larger trial would be needed to determine whether there is any net effect of improvement in weight on under five mortality rate.

引用

页码：823 / 827

页数：4

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