The pathophysiology of varicocele-associated male infertility

被引：45

作者：

Schoor R.A. ^{[1
]}

Elhanbly S.M. ^{[1
]}

Niederberger C.S. ^{[1
]}

机构：

[1] Department of Urology/Andrology, Division of Andrology, University of Illinois at Chicago, 840 South Wood Street, M/C 955, Chicago, 60612-7316, IL

来源：

Current Urology Reports | 2001年 / 2卷 / 6期

关键词：

Male Infertility; Sertoli Cell; Spermatic Vein; Total Antioxidant Capacity; Varicocele;

D O I：

10.1007/s11934-001-0035-7

中图分类号：

学科分类号：

摘要：

Varicocele is the most commonly identifiable, surgically correctable lesion associated with male-factor infertility. Surgical correction of a varicocele, whether unilateral or bilateral, results in improvement not only in semen parameters but also in spontaneous and assisted pregnancy rates. Varicoceles seem to induce a number of changes in the testicular microenvironment. These alterations in temperature, hemodynamics, and reactive oxidative species and antioxidant concentrations have been demon-strated to produce deleterious effects on spermatogenesis. However, despite current knowledge in the patho-physiology of varicocele-associated male infertility, the exact mechanism—or mechanisms—by which varicoceles impair fertility remains elusive. This review examines scientific evidence regarding the pathophysiology of varicocele-associated male infertility. © 2001, Current Science Inc.

引用

页码：432 / 436

页数：4

共 48 条

[1]

Alcalay J., Kedem R., The ethnic distribution of varicocele, Mil Med, 151, pp. 327-328, (1986)

[2]

Jarow J., Coburn M., Sigman M., Incidence of varicoceles in men with primary and secondary infertility, Urol, 47, pp. 73-76, (1996)

[3]

Kursh E., What is the incidence of varicocele in a fertile population, Fertil Steril, 48, pp. 510-511, (1987)

[4]

Meacham R., Townsend D., Rademacher D., Drose J., The incidence of varicoceles in the general population when evaluated by physical examination, gray scale sonography and color doppler sonography, J Urol, 151, pp. 1535-1538, (1994)

[5]

The influence of varicocele on parameters of fertility in a large group of men presenting to infertility clinics, Fertil Steril, 57, pp. 1289-1293, (1992)

[6]

Greenberg S., Varicocele and male infertility, Fertil Steril, 28, (1977)

[7]

Madgar I., Weissenberg R., Lunenfeld B., Et al., Controlled trial of high spermatic vein ligation for varicocele in infertile men, Fertil Steril, 63, pp. 120-124, (1995)

[8]

Holland K., Brill R., Chang R., Et al., Physiological and behav-ioural thermoregulation in bigeye tuna (Thunnus obesus), Nature, 358, pp. 410-412, (1992)

[9]

Schmidt-Nielsen K., Countercurrent systems in animals, Sci Am, 244, pp. 118-128, (1981)

[10]

Stevens E., Lam H., Kendall J., Vascular anatomy of the counter-current heat exchanger of the skipjack tuna, J Exp Biol, 61, pp. 145-153, (1974)

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