Clinical endocrinology of human leptin

被引：74

作者：

Van Gaal L.F. ^{[1
]}

Wauters M.A. ^{[1
]}

Mertens I.L. ^{[1
]}

Considine R.V. ^{[2
]}

De Leeuw I.H. ^{[1
]}

机构：

[1] Department of Endocrinology, Metabolism and Clinical Nutrition, University Hospital Antwerp, Edegem, Antwerp

[2] Division of Endocrinology and Metabolism, Indiana University School of Medicine, Indianapolis, IN

来源：

International Journal of Obesity | 1999年 / 23卷 / Suppl 1期

关键词：

Body fat distribution; Endocrinology; Hormones; Leptin;

D O I：

10.1038/sj.ijo.0800792

中图分类号：

学科分类号：

摘要：

Since the discovery of leptin, a boom of scientific knowledge became available about the OB-protein gene and its role and significance in weight regulation. Both from animal and human research data, serum leptin can probably be considered as one of the best biological markers to reflect total body fat, and this finding is true over a wide range of body mass indexes (BMIs) and in different pathologies: in normal weight, anorexic and obese subjects; in non insulin-dependent diabetes mellitus (NIDDM) patients, PCO women, Prader-Willi children and subjects with hypogonadism and growth hormone deficiency.Gender differences clearly exist, probably related to sex hormone differences, and from fat distribution studies it could be shown that subcutaneous fat is much more related to serum leptin concentrations than visceral fat: also leptin messenger-RNA (m-RNA) expression is significantly higher in subcutaneous fat from human obese subjects.Leptin is not only correlated to a series of endocrine parameters such as insulin, insulin-like growth factor, (IGF) and SHBG, it seems involved as a mediator in some endocrine mechanisms (onset of puberty, insulin secretion, etc) as well.Weight loss will reduce human leptin concentrations, whereas the administration of human recombinant leptin seems to show only limited effects. © 1999 Stockton Press. All rights reserved.

引用

页码：29 / 36

页数：7

共 55 条

[1]

Zhang Y., Proenca R., Maffei M., Barone M., Leopold L., Friedman J.M., Positional cloning of the mouse obese gene and its human homologue, Nature, 372, pp. 425-431, (1994)

[2]

Considine R.V., Leptin and obesity in humans, Eating Weight Disord, 2, pp. 61-66, (1997)

[3]

Considine R.V., Sinha M.K., Heiman M.L., Kriauciunas A., Stephens T.W., Nyce M.R., Ohannesian J.P., Marco C.C., McKee L.J., Bauer T.L., Caro J.F., Serum immunoreactive-leptin concentrations in normal-weight and obese humans, N Engl J Med, 334, pp. 292-295, (1996)

[4]

Weigle D.S., Ganter S.L., Kuijper J.L., Leonetti D.L., Boyko E.J., Fujimoto W.Y., Effect of regional fat distribution and prader-willi syndrome on plasma leptin levels, J Clin Endocrinol Metab, 82, pp. 566-570, (1997)

[5]

Haffner S.M., Gingerich R.L., Miettinen H., Stern M.P., Leptin concentrations in relation to overall adiposity and regional body fat distribution in mexican americans, Int J Obes, pp. 904-908, (1996)

[6]

Lonnqvist F., Arner P., Nordfors L., Schalling M., Overexpression of the obese (Ob) gene in adipose tissue of human obese subjects, Nat Med, 1, pp. 950-953, (1995)

[7]

Montague C.T., Prins J.B., Sanders L., Digby J.E., O'Rahilly S., Depot-and sex-specific differences in human leptin mrna expression. Implications for the control of regional fat distribution, Diabetes, 46, pp. 342-347, (1997)

[8]

Vansant G., Van Gaal L., Van Acker K., De Leeuw I., Importance of glucagon as a determinant of resting metabolic rate and glucose-induced thermogenesis in obese women, Metabolism, 7, pp. 672-675, (1991)

[9]

Widjaja A., Lill C., Radamm C., Otting G., Von Zur Muhler A., Brabant G., Serum leptin levels are not altered in thyroid dysfunction in humans, Leptin: The Voice of Adipose Tissue, pp. 263-268, (1997)

[10]

Campfield L.A., Smith F.J., Burn P., Strategies and potential molecular targets for obesity treatment, Science, 280, pp. 1383-1387, (1998)

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