An impairment of barrier size and charge selectivity of glomerular basement membrane in streptozotocin-induced diabetes and prevention by pharmacological therapy

被引：6

作者：

Isogai S. ^{[1
]}

Mogami K. ^{[1
]}

Ouchi H. ^{[1
]}

Yoshino G. ^{[1
]}

机构：

[1] Department of Medicine, Yamauchi Hospital, Fujisawa, Kanagawa 251-0055

来源：

Medical Electron Microscopy | 2000年 / 33卷 / 3期

关键词：

Anionic sites; Captopril; Glomerular basement membrane; Pore size; Streptozotocin-induced diabetes; Urinary albumin excretion;

D O I：

10.1007/s007950000011

中图分类号：

学科分类号：

摘要：

We examined barrier size (pore size) and charge selectivity (anionic sites) of the glomerular basement membrane (GBM) in experimental diabetes. For estimation of the pore size we employed a new method, tissue negative staining. In diabetic rats, enlarged pores and decreased numbers of anionic sites of GBM were observed. Both insulin treatment and angiotensin-converting enzyme inhibitors prevented these changes. The renoprotective effect of the two drugs is discussed in the article.

引用

页码：123 / 129

页数：6

共 28 条

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